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Cholestenoic acids regulate motor neuron survival via liver X receptors.
Cholestenoic acids are formed as intermediates in metabolism of cholesterol to bile acids, and the biosynthetic enzymes that generate cholestenoic acids are expressed in the mammalian CNS. Here, weExpand
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Cerebrospinal Fluid Steroidomics: Are Bioactive Bile Acids Present in Brain?*
In this study we have profiled the free sterol content of cerebrospinal fluid by a combination of charge tagging and liquid chromatography-tandem mass spectrometry. Surprisingly, the most abundantExpand
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Analytical strategies for characterization of oxysterol lipidomes: liver X receptor ligands in plasma.
Bile acids, bile alcohols, and hormonal steroids represent the ultimate biologically active products of cholesterol metabolism in vertebrates. However, intermediates in their formation, includingExpand
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On the future of “omics”: lipidomics
SummaryFollowing in the wake of the genomic and proteomic revolutions new fields of “omics” research are emerging. The metabolome provides the natural complement to the genome and proteome, however,Expand
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Sterols and oxysterols in plasma from Smith-Lemli-Opitz syndrome patients
Smith-Lemli-Opitz syndrome (SLOS) is a severe autosomal recessive disorder resulting from defects in the cholesterol synthesising enzyme 7-dehydrocholesterol reductase (Δ7-sterol reductase, DHCR7, ECExpand
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Mass Spectrometry for Steroid Analysis
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Shotgun cholanomics of ileal fluid
In this study we have developed a rapid method for the shotgun analysis of bile acids in intestinal fluid. The method is semi-quantitative, and requires little sample preparation. Bile salts mightExpand
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Bile Acid Biosynthesis Avoiding Cholesterol
Bile acids are the end products of cholesterol metabolism secreted into bile. They are essential for the absorption of lipids and lipid soluble compounds from the intestine. Here we have investigatedExpand
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Effects of Dietary Fortification of Vitamin A and Folic Acid on the Composition of Chicken Egg
Micronutrient Malnutrition (MNM) is widespread in the industrialized nations, but more prominent in the developing regions of the world. It affects human of all age groups, but young children andExpand