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Melanopsin and non-melanopsin expressing retinal ganglion cells innervate the hypothalamic suprachiasmatic nucleus
TLDR
It appears that the rod/cone system of photoreceptors may provide signals to the SCN circadian system independent of intrinsically light-sensitive melanopsin ganglion cells.
View on Cambridge Press
A network model of respiratory rhythmogenesis.
TLDR
The model reproduces the experimentally determined trajectories of membrane potential for the five physiologically distinct types of neurons included and is consistent with the concept of a network oscillator as the source of the respiratory rhythm.
View on PubMed
Response of the Mouse Circadian System to Serotonin 1A/2/7 Agonists in vivo: Surprisingly Little
TLDR
The results indicate that in the intact mouse in vivo, acute activation of 5-HT1A/2/7 receptors in the circadian system is not sufficient to reset the SCN pacemaker or to oppose phase-shifting effects of light.
View on SAGE
Computational Aspects of the Respiratory Pattern Generator
TLDR
Results demonstrate that the network model can account for a number of diverse physiological observations, and support the network hypothesis of respiratory rhymogenesis.
View on MIT Press
Light-Induced Fos Expression in Intrinsically Photosensitive Retinal Ganglion Cells in Melanopsin Knockout (Opn4−/−) Mice
TLDR
The results are the first description of a light-evoked response in an ipRGC lacking melanopsin and provide in vivo confirmation of previous in vitro observations illustrating an unusual circuit in the retina in which ganglion cells sending dendrites to the OFF sublamina of the inner plexiform layer receive excitatory synaptic input from ON-bipolar cells.
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Correlation between oscillations in ventilation and frequency content of the electroencephalogram.
TLDR
These data are compatible with the hypothesis that the initiation of apnea in stage 1/2 sleep is related to a reduction in the state-dependent input to the ventilatory control system, and are synchronous within the time resolution of the methodology.
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Photic Entrainment Is Altered in the 5-HT 1B Receptor Knockout Mouse
TLDR
Light-induced phase shifts were reduced in 5-HT1B KO mice, consistent with their behavior in T cycles, suggesting an attenuated response to light, and can be explained by consideration of GABAergic mechanisms within the SCN.
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Suprachiasmatic nucleus input to autonomic circuits identified by retrograde transsynaptic transport of pseudorabies virus from the eye
TLDR
Results indicate that in the rat, as in the hamster, SCN infection after intraocular PRV152 inoculation is by retrograde transsynaptic transport via autonomic pathways to the eye.
View on Wiley
5-HT1B Receptor Knockout Mice Exhibit an Enhanced Response to Constant Light
TLDR
The enhanced response of the SCN circadian clock of the 5- HT1B receptor KO mice to LL conditions is consistent with the hypothesis that the endogenous activation of 5-HT1B presynaptic receptors modulates circadian behavior by attenuating photic input to theSCN.
View on SAGE
Altered Entrainment to the Day/Night Cycle Attenuates the Daily Rise in Circulating Corticosterone in the Mouse
TLDR
Under T cycles <24 h, altered circadian entrainment to short day (winter-like) conditions, manifest as long delays in activity onset after light offset, severely reduces the amplitude of the diurnal rhythm of plasma corticosterone.
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