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Poly-l-Arginine Enhances Paracellular Permeability via Serine/Threonine Phosphorylation of ZO-1 and Tyrosine Dephosphorylation of Occludin in Rabbit Nasal Epithelium
AbstractPurpose. The purpose of the present study is to explore whether a poly-l-arginine (poly-l-Arg)-induced increase in tight junctions (TJ) permeability of fluorescein isothiocyanate-labeledExpand
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Density-dependent proliferation of adult rat hepatocytes in primary culture induced by epidermal growth factor is potentiated by cAMP-elevating agents.
We investigated whether or not epidermal growth factor (EGF) and cAMP-elevating agents induce the proliferation of adult rat hepatocytes during the early (4 h after adding EGF) and late phases (21 hExpand
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Stimulation by transforming growth factor-alpha of DNA synthesis and proliferation of adult rat hepatocytes in primary cultures: modulation by alpha- and beta-adrenoceptor agonists.
  • M. Kimura, M. Ogihara
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental…
  • 1 October 1999
We investigated the effects of transforming growth factor alpha (TGF-alpha) on DNA synthesis and proliferation in primary cultures of adult rat hepatocytes and examined the influence of alpha andExpand
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Effects of branched-chain amino acids on DNA synthesis and proliferation in primary cultures of adult rat hepatocytes.
We investigated the effects of branched-chain amino acids on DNA synthesis and proliferation in primary cultures of adult rat hepatocytes. Of the branched-chain amino acids, only leucineExpand
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Fundamental investigation of a novel drug delivery system, a transdermal delivery system with jet injection
Abstract A new drug delivery system simultaneously using jet injection and a transdermal delivery system was proposed. After pretreatment of hairless rat skin by a jet injector containingExpand
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Analysis of Simultaneous Transport and Metabolism of Ethyl Nicotinate in Hairless Rat Skin
AbstractPurpose. Simultaneous skin transport and metabolism of ethyl nicotinate (EN), a model drug, were measured and theoretically analyzed. Methods. Several permeation studies of EN or itsExpand
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Proliferation of adult rat hepatocytes in primary cultures induced by platelet-derived growth factor is potentiated by phenylephrine.
We investigated whether or not proliferation of adult rat hepatocytes induced by platelet-derived growth factor (PDGF) is affected by alpha1-adrenoceptor agonists such as phenylephrine during theExpand
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  • Open Access
Tumor necrosis factor (TNF) receptor-2-mediated DNA synthesis and proliferation in primary cultures of adult rat hepatocytes: The involvement of endogenous transforming growth factor-alpha.
We investigated the effects of tumor necrosis factor (TNF)-alpha on DNA synthesis and proliferation, and its signal transduction pathways in primary cultures of adult rat hepatocytes. TNF-alphaExpand
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IP receptor agonist-induced DNA synthesis and proliferation in primary cultures of adult rat hepatocytes: the involvement of endogenous transforming growth factor-alpha.
To elucidate the mechanism of action of prostaglandin I(2) (PGI(2)) and carbaprostacyclin, we studied their effect on DNA synthesis and proliferation in primary cultures of adult rat hepatocytes.Expand
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Signal transduction pathway for L-ascorbic acid- and L-ascorbic acid 2-glucoside-induced DNA synthesis and cell proliferation in primary cultures of adult rat hepatocytes.
We examined the effects of L-ascorbic acid and its analogues on DNA synthesis and cell proliferation. We also investigated the signal transduction pathways involved in the induction of mitogenesis byExpand
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  • Open Access