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Mass spectrometry of purified amyloid beta protein in Alzheimer's disease.
The amyloid beta-protein (A beta) that is progressively deposited in Alzheimer's disease (AD) arises from proteolysis of the integral membrane protein, beta-amyloid precursor protein (beta APP).Expand
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Phosphorylated tau protein is integrated into paired helical filaments in Alzheimer's disease.
Antisera to paired helical filaments (PHF) were found to contain a significant amount of tau antibodies specific for a phosphorylated form, but only a negligible amount of those specific for aExpand
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Isoaspartate formation and neurodegeneration in Alzheimer's disease.
We reviewed here that protein isomerization is enhanced in amyloid-beta peptides (Abeta) and paired helical filaments (PHFs) purified from Alzheimer's disease (AD) brains. Biochemical analysesExpand
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Lifespan and Glucose Metabolism in Insulin Receptor Mutant Mice
Insulin/insulin-like growth factor type 1 signaling regulates lifespan and resistance to oxidative stress in worms, flies, and mammals. In a previous study, we revealed that insulin receptor (IR)Expand
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  • Open Access
Mitosis-specific phosphorylation of vimentin by protein kinase C coupled with reorganization of intracellular membranes
Using two types of anti-phosphopeptide antibodies which specifically recognize vimentin phosphorylated by protein kinase C (PKC) at two distinct PKC sites, we found that PKC acted as a mitoticExpand
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Lack of the car☐yl terminal sequence of tau in ghost tangles of Alzheimer's disease
Using seven independent antibodies against the amino terminal to the carboxyl terminal sequence of tau, we biochemically analyzed and compared the neuropathogenesis of two Alzheimer's disease brainsExpand
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Estrogen, Insulin, and Dietary Signals Cooperatively Regulate Longevity Signals to Enhance Resistance to Oxidative Stress in Mice*
To investigate the biological significance of a longevity mutation found in daf-2 of Caenorhabditis elegans, we generated a homologous murine model by replacing Pro-1195 of insulin receptors with LeuExpand
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Spatial Patterns of Ca2+ Signals Define Intracellular Distribution of a Signaling by Ca2+/Calmodulin-dependent Protein Kinase II*
Ca2+ plays a central role in cell signaling, and Ca2+/calmodulin-dependent protein kinase II (CaMKII) is a major mediator of Ca2+actions. The spatial distribution of intracellular Ca2+signaling isExpand
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A possible fetal antigen ofMr70,000 in neurofibrillary tangles
To test the hypothesis that tau-immunoreactive curly fibers represent a regenerative attempt of cortical neurons in the brain affected with Alzheimer's disease (AD), we established 2 monoclonalExpand
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Restoration of the behavioral rates and lifespan in clk-1 mutant nematodes in response to exogenous coenzyme Q10
The clk-1 gene encodes demethoxyubiquinone mono-oxygenase that is necessary for the biosynthesis of coenzyme Q (CoQ), which is an electron transporter in the respiratory chain of mitochondria.Expand
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