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Identification of Innate IL-5–Producing Cells and Their Role in Lung Eosinophil Regulation and Antitumor Immunity
- M. Ikutani, T. Yanagibashi, +8 authors K. Takatsu
- Biology, Medicine
- The Journal of Immunology
- 15 January 2012
It is shown that innate IL-5–producing cells were increased in response to tumor invasion, and their regulation of eosinophils is critical to suppress tumor metastasis and contribute to development of novel immunotherapies for cancer. Expand
Inhibition by evodiamine of hepatocyte growth factor-induced invasion and migration of tumor cells.
Results suggest that evodiamine suppressed HGF-stimulated invasion and migration of tumor cells partly through inhibition of cell spreading. Expand
Anti-invasive and metastatic activities of evodiamine.
- M. Ogasawara, T. Matsunaga, Satoshi Takahashi, I. Saiki, Hideyo Suzuki
- Biological & pharmaceutical bulletin
- 1 November 2002
The results suggest that evodiamine may be useful as a leading compound for agents in tumor metastasis therapy and the presence of a methyl group at N-14 and the configuration of hydrogen at C-13 b may be responsible for the inhibitory activities of evodienine. Expand
Differential effect of intestinal neuropeptides on invasion and migration of colon carcinoma cells in vitro.
Results indicate that VIP, among the neuropeptides used, could inhibit Matrigel invasion of Colon 26-L5 carcinoma cells through partial suppression of their motility, and the reduction was associated with an intracellular cAMP-mediated pathway. Expand
Effect of prostatic neuropeptides on migration of prostate cancer cell lines
- O. Nagakawa, M. Ogasawara, J. Murata, H. Fuse, I. Saiki
- Medicine, Biology
- International journal of urology : official…
- 1 February 2001
Among various neuropeptides in the prostate, calcitonin gene‐related peptide and gastrin‐releasing peptide increased the invasive capacity of PC‐3 prostate cancer cells through enhancement of cell motility, while substance P inhibited the invasiveness through suppression of motile response. Expand
Alpha-melanocyte-stimulating hormone blocks invasion of reconstituted basement membrane (Matrigel) by murine B16 melanoma cells.
The results suggest that alpha-MSH suppressed the invasive and metastatic properties of B 16 melanoma cells, and the degree of inhibition was associated with metastatic potential of B16 melan cancer cells. Expand
Involvement of TNF-alpha in enhancement of invasion and metastasis of colon 26-L5 carcinoma cells in mice by social isolation stress.
The data suggested that isolation stress-augmented TNF-alpha may be involved in the enhancement of tumor invasion and metastasis in part by upregulating the proteolytic enzymes such as MMPs and u-PA in tumor and liver tissues. Expand
Differential effects of antioxidants on the in vitro invasion, growth and lung metastasis of murine colon cancer cells.
- M. Ogasawara, T. Matsunaga, Hideyo Suzuki
- Chemistry, Medicine
- Biological & pharmaceutical bulletin
The results suggest that EGCG is potentially beneficial for tumor metastasis inhibition, but its inhibition of these activities was much less effective than that of other compounds which did not show any antimetastatic effect. Expand
Effect of prostatic neuropeptides on invasion and migration of PC-3 prostate cancer cells.
Results indicate that both GRP and CGRP increased the invasive potential of PC-3 cells probably through enhancement of cell motility, while SP inhibited the invasiveness through suppression of motile response. Expand
Inhibitory effects of evodiamine on in vitro invasion and experimental lung metastasis of murine colon cancer cells.
The results suggest that evodiamine may be regarded as a promising agent in tumor metastasis therapy, whereas cisplatin caused serious weight loss in mice in the experimental period. Expand