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Differential metabolism of dihomo-gamma-linolenic acid and arachidonic acid by cyclo-oxygenase-1 and cyclo-oxygenase-2: implications for cellular synthesis of prostaglandin E1 and prostaglandin E2.
TLDR
It appears that employing a dietary or a combined dietary/pharmacological paradigm to augment the cellular ratio of DGLA/AA is not an effective route to enhance endogenous synthesis of P GE(1) over PGE(2), at least in cells/tissues where COX-1 predominates over COX -2. Expand
Highly unsaturated (n-3) fatty acids, but not alpha-linolenic, conjugated linoleic or gamma-linolenic acids, reduce tumorigenesis in Apc(Min/+) mice.
TLDR
The results suggest that SDA and EPA attenuate tumorigenesis in this model and that this effect may be related in part to alterations in prostaglandin biosynthesis. Expand
Highly Unsaturated (n-3) Fatty Acids, but Not α-Linolenic, Conjugated Linoleic or γ-Linolenic Acids, Reduce Tumorigenesis in ApcMin/+ Mice
TLDR
The results suggest that SDA and EPA attenuate tumorigenesis in this model and that this effect may be related in part to alterations in prostaglandin biosynthesis. Expand
Novel, selective Δ6 or Δ5 fatty acid desaturase inhibitors as antiinflammatory agents in mice
TLDR
The Delta6 desaturase may be a target for development of antiinflammatory drugs whose mechanism of action is unique because of its correlation existed between inhibition of liver Delta6 Desaturase activity and decreases in edema. Expand
Novel, selective delta6 or delta5 fatty acid desaturase inhibitors as antiinflammatory agents in mice.
TLDR
The Delta6 desaturase may be a target for development of antiinflammatory drugs whose mechanism of action is unique because of its correlation existed between inhibition of liver Delta6 Desaturase activity and decreases in edema. Expand
ULTRASTRUCTURE AND PHENOLIC HISTOCHEMISTRY OF THE CYCAS REVOLUTA‐ANABAENA SYMBIOSIS
TLDR
Anabaena showed a seasonal difference in nitrogen storage when growing in Cycas revoluta coralloid roots, and the distribution of phenolic constituents could provide a mechanism for excluding micro-organisms and permitting only Anabaena to grow in cycad coralloids roots. Expand
Fish oil inhibits Δ6 desaturase activity in vivo: Utility in a dietary paradigm to obtain mice depleted of arachidonic acid
TLDR
The inhibition of Δ6 desaturase activity by n-3 PUFAs provides a basis for a unique dietary route to selectively reduce tissue arachidonic acid, while providing sufficient linoleic acid, an essential fatty acid, to support normal cellular metabolism. Expand
Selective inhibition of Delta-6 desaturase impedes intestinal tumorigenesis.
TLDR
The effects of a novel selective Delta-6 desaturase inhibitor, SC-26196, on tumorigenesis in two in vivo models of intestinal cancer are reported and it is reported that the observed effects were due to interference with the biosynthetic pathway of arachidonic acid. Expand
Identification and characterization of a novel delta6/delta5 fatty acid desaturase inhibitor as a potential anti-inflammatory agent.
TLDR
Results suggest that delta5 and/or delta6 desaturase inhibitors have the potential to manifest an anti-inflammatory response by decreasing the level of AA and the ensuing production of eicosanoids. Expand
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