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Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans Published, JLR Papers in Press, September 8, 2005. DOI 10.1194/jlr.M500294-JLR200
TLDR
It is demonstrated that >90% of all macrophages in WAT of obese mice and humans are localized to dead adipocytes, where they fuse to form syncytia that sequester and scavenge the residual “free” adipocyte lipid droplet and ultimately form multinucleate giant cells, a hallmark of chronic inflammation. Expand
Obesity and the role of adipose tissue in inflammation and metabolism.
TLDR
Understanding of the adipocyte as an endocrine organ is leading to new insights into obesity and health, and exercise activates the AMP-activated protein kinase (AMPK) in muscle and other tissues, a pathway that increases fat oxidation and glucose transport. Expand
Estrogen Regulation of Adiposity and Fuel Partitioning
TLDR
Novel genomic and non-genomic actions of E2 promote leanness in OVX mice independently of reduced energy intake, and appears to promote the partitioning of free fatty acids toward oxidation and away from triglyceride storage by up-regulating the expression of peroxisome proliferation activator receptor-δ and its downstream targets. Expand
Analysis of Lipolytic Protein Trafficking and Interactions in Adipocytes*
TLDR
Results indicate that Plin mediates hormone-stimulated lipolysis via direct and indirect mechanisms. Expand
The gut microbiota, obesity and insulin resistance.
TLDR
Differences in community composition, functional genes and metabolic activities of the gut microbiota appear to distinguish lean vs obese individuals, suggesting that gut 'dysbiosis' contributes to the development of obesity and/or its complications. Expand
Modulation of gut microbiota during probiotic-mediated attenuation of metabolic syndrome in high fat diet-fed mice
TLDR
The results suggest that Lactobacillus and Bifidobacterium differentially attenuate obesity comorbidities in part through strain-specific impacts on MS-associated phylotypes of gut microbiota in mice. Expand
Control of Adipose Triglyceride Lipase Action by Serine 517 of Perilipin A Globally Regulates Protein Kinase A-stimulated Lipolysis in Adipocytes*
TLDR
Serine 517 is identified as the Peri A PKA site essential for ATGL-dependent lipolysis and a novel “master regulator” of PKA-stimulated adipocytelipolysis. Expand
Dietary blueberry attenuates whole-body insulin resistance in high fat-fed mice by reducing adipocyte death and its inflammatory sequelae.
TLDR
It is suggested that cytoprotective and antiinflammatory actions of dietary BB can provide metabolic benefits to combat obesity-associated pathology. Expand
Adipocyte Death, Adipose Tissue Remodeling, and Obesity Complications
TLDR
These results implicate depot-selective adipocyte death and MΦ-mediated AT remodeling in inflammatory and metabolic complications of murine obesity. Expand
Perilipin Promotes Hormone-sensitive Lipase-mediated Adipocyte Lipolysis via Phosphorylation-dependent and -independent Mechanisms*
TLDR
It is demonstrated by cell fractionation and confocal microscopy that up to 50% of cellular HSL is LD-associated in the basal state and that PKA-stimulated HSL translocation is fully supported by adenoviral expression of a mutant perilipin lacking all six PKA sites (Peri AΔ1–6). Expand
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