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Phosphatidylglycerolphosphate synthase encoded by the PEL1/PGS1 gene in Saccharomyces cerevisiae is localized in mitochondria and its expression is regulated by phospholipid precursors
Abstract The PEL1/PGS1 gene of the yeast Saccharomyces cerevisiae is essential for the viability of rho–/rho° mutants and the normal cardiolipin content of cells. The PEL1-GFP fusion gene has beenExpand
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A real-time PCR diagnostic method for detection of Naegleria fowleri.
Naegleria fowleri is a free-living amoeba that can cause primary amoebic meningoencephalitis (PAM). While, traditional methods for diagnosing PAM still rely on culture, more current laboratoryExpand
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Induction of respiration-deficient mutants in Saccharomyces cerevisiae by chelerythrine.
Chelerythrine and sanguinarine, two structurally related benzo/c/phenanthridine alkaloids, prevented growth of yeast cells in medium containing either glucose or non-fermentable carbon sources. AtExpand
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Production of squalene by lactose‐fermenting yeast Kluyveromyces lactis with reduced squalene epoxidase activity
Utilization of yeast as squalene source for commercial use is limited by relatively high production costs. The ability of Kluyveromyces lactis to grow on cheap lactose‐containing diary industryExpand
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Role of the PDR Gene Network in Yeast Susceptibility to the Antifungal Antibiotic Mucidin
ABSTRACT Yeast strains disrupted in the PDR1, PDR3, or PDR5 gene, but not in SNQ2, exhibited higher sensitivity to mucidin (strobilurin A) than did the isogenic wild-type strains. DifferentExpand
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Growth of eukaryotic cells in relation to the structure of mitochondrial membranes and mitochondrial genome
Viability ofpetite-negative yeast, such asKluyveromyces lactis, is dependent on functional mitochondrial genome encoding essential components of both mitochondrial protein synthesizing system andExpand
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Ofloxacin induces cytoplasmic respiration-deficient mutants in yeast Saccharomyces cerevisiae
SummaryOfloxacin, a new quinolone with potent antibacterial activity, was also found to be effective against yeast. At relatively high concentrations, and at mild alkaline pH, ofloxacin inhibited theExpand
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Cross-resistance to strobilurin fungicides in mitochondrial and nuclear mutants ofSaccharomyces cerevisiae
In yeast the resistance to kresoxim-methyl and azoxystrobin, like the resistance to strobilurin A (mucidin) is under the control of both mitochondrialcob gene and the PDR network of nuclear genesExpand
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The pel1 mutant of Saccharomyces cerevisiae is deficient in cardiolipin and does not survive the disruption of the CHO1 gene encoding phosphatidylserine synthase.
Cells of the pel1 mutant of Saccharomyces cerevisiae were found to contain an extremely low content of cardiolipin, a decreased level of phosphatidylcholine and an increased level ofExpand
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The KlPGS1 gene encoding phosphatidylglycerolphosphate synthase in Kluyveromyces lactis is essential and assigned to chromosome I.
The phosphatidylglycerolphosphate synthase (CDP-diacylglycerol:sn-glycerol-3-phosphate 3-phosphatidyltransferase, EC is an essential enzyme in biosynthesis of cardiolipin. In this work weExpand
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