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FKBP12.6-Mediated Stabilization of Calcium-Release Channel (Ryanodine Receptor) as a Novel Therapeutic Strategy Against Heart Failure
Background—The development of heart failure is tightly correlated with a decrease in the stoichiometric ratio for FKBP12.6 binding to the ryanodine receptor (RyR) in the sarcoplasmic reticulum (SR).Expand
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Ser-2030, but not Ser-2808, is the major phosphorylation site in cardiac ryanodine receptors responding to protein kinase A activation upon beta-adrenergic stimulation in normal and failing hearts.
We have recently shown that RyR2 (cardiac ryanodine receptor) is phosphorylated by PKA (protein kinase A/cAMP-dependent protein kinase) at two major sites, Ser-2030 and Ser-2808. In the presentExpand
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Regulation of the activity of branched‐chain 2‐oxo acid dehydrogenase (BCODH) complex by binding BCODH kinase
Branched‐chain 2‐oxo acid dehydrogenase (BCODH) kinase is responsible for inactivation of BCODH complex by phosphorylation of the complex. Activity of the kinase towards its substrate, the E1Expand
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Structure-activity relationships in the C-terminal part of luteinizing hormone releasing hormone(LH-RH).
Abstract Five new analogs of LH-RH(pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2), ( Des-Gly-NH 2 10 , Pro-methylamide9)-LH-RH, ( Des-Gly-NH 2 10 , Pro-propylamide9)-LH-RH, ( Des-Gly-NH 2 10 ,Expand
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The use of N-hydroxy-5-morbornene-2,3-dicarboximide active esters in peptide synthesis.
N-Hydroxy-5-norbornene-2, 3-dicarboximide (HONB) was found to be an excellent reagent to be used in couple with N, N'-dicyclohexylcarbodiimide (DCC) for the peptide synthesis. Various racemizationExpand
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Synthesis and biological activities of analogs of luteinizing hormone releasing hormone (LH-RH).
Twenty analogs of luteinizing hormone releasing hormone (LH-RH or pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2), i.e., , , [Pro1]-, [Phe2]-, [3-Me-His2]-, [Lys2]-, [Arg2]-, [Ala4]-, [Thr4]-, [Gln5]-,Expand
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Dose-dependent effect of ANG II-receptor antagonist on myocyte remodeling in rat cardiac hypertrophy.
The goal of this study was to examine the effect of an angiotensin II type 1 (AT1)-receptor antagonist (TCV-116) on left ventricular (LV) geometry and function during the development ofExpand
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AT1 receptor antagonist restores cardiac ryanodine receptor function, rendering isoproterenol-induced failing heart less susceptible to Ca2+ -leak induced by oxidative stress.
BACKGROUND The Ca(2+) regulatory proteins in the sarcoplasmic reticulum (SR) play a key role in the pathogenesis of heart failure. In the present study the effect of chronic beta-receptor-stimulationExpand
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