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Prevention of colorectal cancer by colonoscopic polypectomy. The National Polyp Study Workgroup.
The results of the National Polyp Study support the view that colorectal adenomas progress to adenocarcinomas, as well as the current practice of searching for and removing adenomatous polyps to prevent coloreCTal cancer. Expand
Comparison of Microsatellite Instability, CpG Island Methylation Phenotype, BRAF and KRAS Status in Serrated Polyps and Traditional Adenomas Indicates Separate Pathways to Distinct Colorectal
The data provided a less complete picture of a second serrated pathway, identified by a KRAS2 mutation in SAs, but showed that the progressive stages of both iterations of the serrated neoplasia pathway are separate and distinct from those of the traditional adenoma-carcinoma sequence. Expand
Colonoscopic polypectomy and long-term prevention of colorectal-cancer deaths.
Findings support the hypothesis that colonoscopic removal of adenomatous polyps prevents death from colorectal cancer. Expand
Serrated Lesions of the Colorectum: Review and Recommendations From an Expert Panel
It is recommended that all serrated lesions proximal to the sigmoid colon and allserrated lesions in the rectosigmoid >5 mm in size, be completely removed. Expand
Randomized comparison of surveillance intervals after colonoscopic removal of newly diagnosed adenomatous polyps. The National Polyp Study Workgroup.
Colonoscopy performed three years after colonoscopic removal of adenomatous polyps detects important colonic lesions as effectively as follow-up colonoscopy after both one and three years. Expand
BRAF and KRAS Mutations in Hyperplastic Polyps and Serrated Adenomas of the Colorectum: Relationship to Histology and CpG Island Methylation Status
A similar high frequency of KRAS or BRAF mutations across the histologic spectrum of the serrated polyps assayed suggests that these are early events in theserrated polyp neoplasia pathway and the association of higher levels of CpG island methylation with more advanced histologic changes suggests that C pG islandmethylation plays a role in serratedpolyp progression toward colorectal carcinoma. Expand
The National Polyp Study. Patient and polyp characteristics associated with high-grade dysplasia in colorectal adenomas.
Adenoma size and the extent of the villous component were found to be the major independent polyp risk factors associated with high-grade dysplasia (p less than 0.0001) in patients discovered to have one or more colorectal adenomas. Expand
Guidelines for Colonoscopy Surveillance after Polypectomy: A Consensus Update by the US Multi‐Society Task Force on Colorectal Cancer and the American Cancer Society * , †
A careful analytic approach was designed addressing all evidence available in the literature to delineate predictors of advanced pathology, both cancer and advanced adenomas, so that patients can be more definitely stratified at their baseline colonoscopy into those at lower or increased risk for a subsequent advanced neoplasia. Expand
Nonpolypoid neoplastic lesions of the colorectal mucosa.
Variation in the Detection of Serrated Polyps in an Average Risk Colorectal Cancer Screening Cohort
Endoscopy and pathology practices should consider educational interventions to improve serrated polyp detection and standardize classification in an average risk-screening cohort at an urban academic medical center. Expand