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Complement Inhibitor of C5 Activation from the Soft Tick Ornithodoros moubata
TLDR
OmCI is the first lipocalin family member shown to inhibit C and also the first natural inhibitor that specifically targets the C5 activation step. Expand
Structural basis for therapeutic inhibition of complement C5
TLDR
A new protein family of tick-derived C5 inhibitors is identified and characterize, revealing three distinct binding sites on C5 that all prevent activation of C5 and suggesting that a priming event is needed for activation. Expand
Potential Risks Associated with the Proposed Widespread Use of Tamiflu
TLDR
It is predicted that high concentrations of OC capable of inhibiting influenza virus replication would be sustained for periods of several weeks, presenting an increased risk for the generation of antiviral resistance and genetic exchange between influenza viruses in wildfowl. Expand
Crystal structure and functional characterization of an immunomodulatory salivary cystatin from the soft tick Ornithodoros moubata.
TLDR
It is concluded that OmC2 is a promising target for the development of a novel anti-tick vaccine to control O. moubata populations and combat the spread of associated diseases. Expand
West Nile virus vector Culex modestus established in southern England
TLDR
Mosquito larval surveys carried out in 2010 identified substantial populations of Cx. Expand
The British river of the future: how climate change and human activity might affect two contrasting river ecosystems in England.
TLDR
An increasing demand for water in southern England due to an expanding population, a possibly reduced flow due to climate change, together with the Water Framework Directive obligation to maintain water quality, will put extreme pressure on river ecosystems, such as the Thames. Expand
An ion-channel modulator from the saliva of the brown ear tick has a highly modified Kunitz/BPTI structure.
TLDR
Consistent with the conversion of this loop into a beta-strand, Ra-KLP shows no significant anti-protease activity; however, it activates maxiK channels in an in vitro system, suggesting a potential mechanism for regulating host blood supply during feeding. Expand
Complement C5 Activation during Influenza A Infection in Mice Contributes to Neutrophil Recruitment and Lung Injury
TLDR
Data suggest that targeting C5 activation with OmCI during IAV infection could be a promising approach to reduce excessive inflammatory reactions associated with the severe forms of IAV infections. Expand
Novel Immunomodulators from Hard Ticks Selectively Reprogramme Human Dendritic Cell Responses
TLDR
It is found that Japanin specifically reprogrammes DC responses to a wide variety of stimuli in vitro, radically altering their expression of co-stimulatory and co-inhibitory transmembrane molecules and their secretion of pro-inflammatory, anti-inflammatory and T cell polarising cytokines. Expand
Alphacoronavirus detected in bats in the United Kingdom.
TLDR
Alphacoronavirus strains were detected in two of seven bat species, namely Myotis nattereri and M. daubentonii, presenting the first record of coronavirus in British bats. Expand
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