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A genome-wide association study identifies susceptibility loci for ovarian cancer at 2q31 and 8q24
Ovarian cancer accounts for more deaths than all other gynecological cancers combined. To identify common low-penetrance ovarian cancer susceptibility genes, we conducted a genome-wide association… Expand
A Lin-9 complex is recruited by B-Myb to activate transcription of G2/M genes in undifferentiated embryonal carcinoma cells
It has recently been discovered that cell-cycle gene transcription is regulated by a core complex named LINC that switches from a transcriptionally repressive complex in G0–G1 with the p130 or p107… Expand
Common variants at 19p13 are associated with susceptibility to ovarian cancer
Epithelial ovarian cancer (EOC) is the leading cause of death from gynecological malignancy in the developed world, accounting for 4% of the deaths from cancer in women. We performed a three-phase… Expand
Common alleles in candidate susceptibility genes associated with risk and development of epithelial ovarian cancer
- M. Notaridou, L. Quaye, +47 authors Susan J. Ramus
- Biology, Medicine
- International journal of cancer
- 1 May 2011
Common germline genetic variation in the population is associated with susceptibility to epithelial ovarian cancer. Microcell‐mediated chromosome transfer and expression microarray analysis… Expand
In vitro three-dimensional modeling of fallopian tube secretory epithelial cells
BackgroundFallopian tube secretory epithelial cells (FTSECs) have been implicated as a cell-of-origin for high-grade serous epithelial ovarian cancer. However, there are relatively few in vitro… Expand
Modelling genetic and clinical heterogeneity in epithelial ovarian cancers.
The biology underlying early-stage epithelial ovarian cancer (EOC) development is poorly understood. Identifying biomarkers associated with early-stage disease could have a significant impact on… Expand
Functional complementation studies identify candidate genes and common genetic variants associated with ovarian cancer survival.
Common germline genetic variation and/or somatic alterations in tumours may be associated with survival in women diagnosed with ovarian cancer. The successful identification of genetic associations… Expand
Correction of Murine Diabetic Hyperglycaemia With A Single Systemic Administration of An AAV2/8 Vector Containing A Novel Codon Optimized Human Insulin Gene.
We report the correction of hyperglycemia of STZ induced diabetic mice using one intravenous systemic administration of a single stranded serotype 8 pseudotyped adeno-associated virus (ssAAV2/8)… Expand
Immunosuppression overcomes insulin- and vector-specific immune responses that limit efficacy of AAV2/8-mediated insulin gene therapy in NOD mice
We report the restoration of euglycaemia in chemically induced diabetic C57BL/6 mice and spontaneously diabetic Non Obese Diabetic (NOD) mice by intravenous systemic administration of a… Expand
Corrigendum: Common variants at 19p13 are associated with susceptibility to ovarian cancer.
Author(s): Bolton, Kelly L; Tyrer, Jonathan; Song, Honglin; Ramus, Susan J; Notaridou, Maria; Jones, Chris; Sher, Tanya; Gentry-Maharaj, Aleksandra; Wozniak, Eva; Tsai, Ya-Yu; Weidhaas, Joanne; Paik,… Expand