Okadaic acid, useful tool for studying cellular processes.
- J. J. Fernández, M. Candenas, M. L. Souto, M. Trujillo, M. Norte
- BiologyCurrent Medicinal Chemistry
- 2002
It has been demonstrated that OA is a highly selective inhibitor of protein phosphatases type 1 (PP1) and 2A (PP2A), subsequently that it causes dramatic increases in phosphorylation of numerous proteins as well as being a potent tumour promoter.
Yessotoxins, a Group of Marine Polyether Toxins: an Overview
- B. Paz, A. Daranas, M. Norte, P. Riobó, J. Franco, J. J. Fernández
- Biology, Environmental ScienceMarine Drugs
- 1 March 2008
Current knowledge on the origin, producer organisms and vectors, chemical structures, metabolism, biosynthetic origin, toxicological properties, potential risks to human health and advances in detection methods of YTXs are covered.
Toxic marine microalgae.
- A. Daranas, M. Norte, J. J. Fernández
- EngineeringToxicon
- 1 August 2001
Oxasqualenoids from Laurencia viridis: Combined Spectroscopic-Computational Analysis and Antifouling Potential.
- F. Cen-Pacheco, Adrián J Santiago-Benítez, A. Daranas
- ChemistryJournal of Natural Products
- 17 March 2015
The biological activities of the new metabolites and other related oxasqualenoids were evaluated for the first time against a panel of relevant biofouling marine organisms, and structure-activity conclusions were obtained.
Dinoflagellate polyether within the yessotoxin, pectenotoxin and okadaic acid toxin groups: characterization, analysis and human health implications.
- H. J. Domínguez, B. Paz, A. Daranas, M. Norte, J. Franco, J. J. Fernández
- MedicineToxicon
- 15 August 2010
Identification of new okadaic acid derivatives from laboratory cultures of Prorocentrum lima.
- J. J. Fernández, B. Suárez-Gómez, M. L. Souto, M. Norte
- ChemistryJournal of Natural Products
- 12 September 2003
The isolation and spectroscopic structural elucidation of new compounds related to DSP toxins, isolated from a laboratory culture of strain PLV2, were reported.
Stereochemical Determination of Five-Membered Cyclic Ether Acetogenins Using a Spin-Spin Coupling Constant Approach and DFT Calculations
- Adrián Gutiérrez-Cepeda, A. Hernández Daranas, J. J. Fernández, M. Norte, M. L. Souto
- ChemistryMarine Drugs
- 1 July 2014
An application of a recently reported simple and efficient NMR protocol based on the measurement of spin-spin coupling constants to achieve the challenging relative configurations of five new halogenated C15 tetrahydrofuranyl-acetogenins, marilzafurollenes A–D and 12-acetoxy-marilZafurenyne, isolated from the red alga, Laurencia marilZae are described.
Cytotoxic oxasqualenoids from the red alga Laurencia viridis.
- F. Cen-Pacheco, J. Villa-Pulgarín, F. Mollinedo, M. Norte, A. Daranas, J. J. Fernández
- Chemistry, BiologyEuropean journal of medicinal chemistry
- 1 August 2011
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