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Insertion of an amino acid in the DNA-binding domain of the glucocorticoid receptor as a result of alternative splicing.
TLDR
A new variant of the glucocorticoid receptor (GRgamma) is described in which, as a result of alternative splicing, three bases are retained from the intron separating exons 3 and 4 that code for an additional amino acid (arginine) in the DNA binding domain of the receptor. Expand
Cross-talk between Stat5b and estrogen receptor- and - in mammary epithelial cells
TLDR
It is demonstrated that estrogen receptor- and - (ER) are both able to potentiate transcription from a Stat5-responsive promoter when activated by prolactin, and that ER and ER act as coactivators for Stat5b through a mechanism which is independent of AF-1 and AF-2. Expand
Antagonism of thyroid hormone action by amiodarone in rat pituitary tumor cells.
TLDR
It is reported that the benzofuran amiodarone acts as a competitive antagonist to thyroid hormone action as defined by its dose-dependent ability to bind to the thyroid hormone receptor and inhibit T3-induced increases in growth hormone mRNA levels in a cultured rat pituitary cell line, GC cells. Expand
Prolactin stimulates the JAK2 and focal adhesion kinase pathways in human breast carcinoma T47-D cells.
TLDR
Findings identify a new protein tyrosine kinase pathway in the action of the lactogenic hormone rhPRL and represent the first report that a hormone acting through a member of the haemopoietin receptor superfamily can regulate the FAK/paxillin pathway. Expand
Cross-talk between Stat5b and estrogen receptor-alpha and -beta in mammary epithelial cells.
TLDR
It is demonstrated that estrogen receptor-alpha and -beta are both able to potentiate transcription from a Stat5-responsive promoter when activated by prolactin, and it is concluded that ERalpha and ERbeta act as coactivators for Stat5b through a mechanism which is independent of AF-1 and AF-2. Expand
Alanine-scanning mutagenesis of human prolactin: importance of the 58-74 region for bioactivity.
TLDR
Ten alanine mutants of human PRL, a member of the PRL/GH family, are generated to investigate the involvement of the highly conserved 58-74 region in the biological behavior of the protein and it is suggested that the binding of these hormones to the lactogenic receptors occurs through a different molecular mechanism having distinct requirements at the residue level. Expand
Corpus luteum - uterine relationships in the control of uterine contraction in the lizard Anolis carolinensis.
TLDR
Investigation of the control of unilateral uterine contraction by exposing uteri to arginine vasotocin (AVT) in vitro found that in cycling Anolis females, the uterus on the same side as an ovary with a large corpus luteum failed to contract in vitro in response to AVT. Expand
The rat growth hormone gene contains multiple thyroid response elements.
TLDR
The results suggest that several different receptor-binding elements interact to control thyroid hormone responsiveness of the rat growth hormone gene and reveal common sequences that may be important for receptor-DNA recognition. Expand
A practical method for staging metamorphosis in the tiger salamander Ambystoma tigrinum
  • M. Norman
  • Biology, Medicine
  • The Anatomical record
  • 1 January 1985
TLDR
Developing a set of practical metamorphic stages for the tiger salamander Ambystoma tigrinum that would provide an early and quantifiable marker of the onset of metamorphosis and not be dependent on knowledge of maximal values of gill length or tail height is developed. Expand
Adenohypophysial-thyroid activity of the tiger salamander, Ambystoma tigrinum, as a function of metamorphosis and captivity.
TLDR
Results indicate that adenohypophysial activation occurs rapidly and is maximal at the onset of metamorphic climax. Expand
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