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Regulation of Postnatal Lung Development and Homeostasis by Estrogen Receptor β
It is shown that ERβ is abundantly expressed and biologically active in the lung, and direct transcriptional regulation of these genes by ERβ was demonstrated, suggesting that estrogens act via ERβ in the lungs to modify PDGF-A and GM-CSF expression.
C/EBP transcription factors in the lung epithelium.
  • T. Cassel, M. Nord
  • Biology, Medicine
    American journal of physiology. Lung cellular and…
  • 1 October 2003
A picture is emerging in which C/EBPalpha has a role in regulating proliferation as well as differentiation-dependent gene expression, whereas C/EBPbeta and -delta, in addition to a partly overlapping role in regulates expression of differentiation markers, also seem to be involved in responses to injury and hormones.
C/EBPalpha and C/EBPdelta activate the clara cell secretory protein gene through interaction with two adjacent C/EBP-binding sites.
It is demonstrated that C/EBPalpha and C/EBPdelta regulate the CCSP gene through a compound response element and suggested that these factors are important for the differentiation-dependent expression of CCSP.
Differential regulation of Estrogen Receptor (ER)α and ERβ in primate mammary gland
Control of gonadal hormone receptors during the menstrual cycle, pregnancy, and lactation in rhesus monkey mammary gland is reported on and it is found that ERα but not ERβ is down-regulated when E2 levels increase and when cells enter the cell cycle.
Increased levels of cysteinyl-leukotrienes in saliva, induced sputum, urine and blood from patients with aspirin-intolerant asthma
Findings support a global and specific increase in CysLT production in aspirin-intolerant asthma.
C/EBP α and C/EBP δ Activate the Clara Cell Secretory Protein Gene through Interaction with Two Adjacent C/EBP-Binding Sites
Immunofluorescence studies demonstrated high level expression of C/EBP δ in the bronchiolar epithelium as well as lower levels of C-EBP α in the distal lung, andDNase I footprint analyses revealed a footprint region located at − 100 to − 62 bp, corresponding to two C-binding sites.
Allergen provocation increases TH2‐cytokines and FOXP3 expression in the asthmatic lung
Allergen provocation increases TH2‐cytokines and FOXP3 expression in the asthmatic lung and this increases the likelihood of asthma in patients with a history of asthma.
Regulation of CCSP (PCB-BP/uteroglobin) expression in primary cultures of lung cells: involvement of C/EBP.
The results show that primary cultures of Clara cells constitute a useful model for investigating terminal airway differentiation and suggest a role for C/EBP-factor(s) in this process.
Clara cell secretory protein: a determinant of PCB bioaccumulation in mammals.
It is demonstrated that CCSP is the determinant for MeSO2-PCB accumulation within mice and the notion that bioconcentration of MeSO 2- PCB pollutants occurs at sites of CCSP localization, such as the respiratory and reproductive tracts of humans, is supported.
Decreased serum and bronchoalveolar lavage levels of clara cell secretory protein (CC16) is associated with bronchiolitis obliterans syndrome and airway neutrophilia in lung transplant recipients1
Serum CCSP could have a potential as an early marker for BOS, and the correlation between decreased CCSP and increased neutrophils in BAL suggests a loss of local airway defense capacity in BOS.