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Inhibitory mechanisms of flavonoids on insulin-stimulated glucose uptake in MC3T3-G2/PA6 adipose cells.
Although genistein, silybin, EGCG and theaflavins had no effect on the insulin-stimulated activation of Akt, they blocked insulin-dependent GLUT4 translocation and provided novel insights into the modulation by flavonoids of insulin's actions, including glucose uptake in adipocytes.
P-Glycoprotein-Dependent Disposition Kinetics of Tacrolimus: Studies in mdr la Knockout Mice
The pharmacokinetic behavior of FK506 in the tissue distribution is related with the function of P-glycoprotein encoded by themdr la gene and the brain distribution is dominated by the P- Glycoprotein-mediated drug efflux and presumably also by the binding to FK-binding proteins (immunophilins) in the brain.
Antitumor Activity of Oenothein B, a Unique Macrocyclic Ellagitannin
- K. Miyamoto, M. Nomura, T. Okuda
- Biology, ChemistryJapanese journal of cancer research : Gann
- 1 January 1993
Results suggest that oenothein B exerts its antitumor effect through potentiation of the host‐immune defense via activation of macrophages.
Mitogen- and Stress-activated Protein Kinase 1 Mediates Activation of Akt by Ultraviolet B Irradiation*
Investigation of the mechanism by which UVB irradiation activates Akt in mouse epidermal JB6 cells suggested that UVB-induced Akt activation was mediated through Msk1, which is a downstream kinase of the Erk and p38 kinase signaling pathways.
Signal Transduction Pathways Involved in Phosphorylation and Activation of p70S6K Following Exposure to UVA Irradiation*
Results suggest that activation of MAPKs, like PI 3-kinase/mTOR, may be involved in UVA-induced phosphorylation and activation of p70S6K.
Suppression of skin tumorigenesis in c-Jun NH(2)-terminal kinase-2-deficient mice.
It is shown that in JNK2-deficient (Jnk2(-/-)) mice, the multiplicity of papillomas induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) was lower than that in wild-type mice, and data suggest that J NK2 is critical in the tumor promotion process.
Lowered blood concentration of tacrolimus and its recovery with changes in expression of CYP3A and P-Glycoprotein after high-dose steroid therapy
The results indicate that the decrease in the blood FK506 concentration caused by high-dose steroid therapy is a consequence of the induction of P-glycoprotein and CYP3A in the liver and intestine, and these changes were reversed within 2 weeks after cessation of steroid therapy.
Pharmacokinetic advantage of intraperitoneal injection of docetaxel in the treatment for peritoneal dissemination of cancer in mice
- T. Shimada, M. Nomura, Y. Yonemura
- Medicine, BiologyThe Journal of pharmacy and pharmacology
- 1 February 2005
Results indicated that the intraperitoneal administration of docetaxel for peritoneal dissemination was likely to be an effective treatment method, without causing any increase in systemic toxicity.
Antitumor activities of ellagitannins against sarcoma-180 in mice.
- K. Miyamoto, M. Nomura, T. Okuda
- Chemistry, MedicineBiological & pharmaceutical bulletin
- 15 April 1993
It is suggested that tannins need the ellagitannin monomer units, having galloyl groups at the O-2 and O-3 positions on the glucose core(s), such as tellimagrandins, in order to exhibit a strong antitumor activity.
Inhibition of Ultraviolet B–Induced AP‐1 Activation by Theaflavins From Black Tea
It is found that theaflavins significantly inhibited activation of extracellular signal‐regulated protein kinases and c‐jun NH2‐terminal kinases, which may further explain the anti–tumor promotion action of these tea constituents.