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High-performance liquid chromatography–tandem mass spectrometry in the identification and determination of phase I and phase II drug metabolites
Applications of tandem mass spectrometry (MS/MS) techniques coupled with high-performance liquid chromatography (HPLC) in the identification and determination of phase I and phase II drug metabolites
High-performance liquid chromatographic determination of tramadol and its O-desmethylated metabolite in blood plasma. Application to a bioequivalence study in humans.
TLDR
Simultaneous HPLC determination of the analgetic agent tramadol, its major pharmacodynamically active metabolite (O-desmethyltramadol) in human plasma is described and the validated analytical method was applied to pharmacokinetic studies of tramadl in human volunteers.
Examination of the Functional Activity of P-glycoprotein in the Rat Placental Barrier Using Rhodamine 123
TLDR
Data suggest that P-gp limits the entry of Rho123 into fetuses and at the same time it accelerates the feto-maternal elimination of the model compound.
Role of carbonyl reducing enzymes in the phase I biotransformation of the non-steroidal anti-inflammatory drug nabumetone in vitro
TLDR
Evidence is provided for the first time evidence that seven specific carbonyl reducing enzymes participate in nabumetone metabolism.
Miotic action of tramadol is determined by CYP2D6 genotype.
TLDR
The concept of dual opioid/non-opioid action of the drug, though considerably stronger in EMs, is valid for both EM and PM subjects, and is the theoretical basis for the frequent use and satisfactory efficacy of tramadol in clinical practice when given to genetically non-selected population.
Pharmacokinetics of tramadol is affected by MDR1 polymorphism C3435T
TLDR
A large number of MDR1 genotype-dependent variations in pharmacokinetic parameters of tramadol and O-demethyltramadol were uncovered, and a similar trend was not observed for M1, for which production was more dependent on relative numbers of CYP2D6 extensive metabolizers.
Analytical power of LLE-HPLC-PDA-MS/MS in drug metabolism studies: identification of new nabumetone metabolites.
TLDR
A new, as yet unreported phase I metabolite was discovered within the evaluation of nabumetone metabolism by human and rat liver microsomal fractions, and the most likely structure was 4-(6-methoxy- 2-naphthyl)-3-hydroxybutan-2-one (3-Hydroxy nabumETone).
High-performance liquid chromatographic determination of tramadol in human plasma.
TLDR
Tramadol has been determined in human plasma samples using a sensitive high-performance liquid chromatographic method and analyses of the extracts were performed on reversed-phase silica gel using ion-pair chromatography and fluorescence detection.
High-performance liquid-chromatographic determination of 5-aminosalicylic acid and its metabolites in blood plasma.
TLDR
New HPLC bioanalytical method for the determination of 5-ASA and its metabolites in blood plasma was developed and validated and was applied to pharmacokinetic studies of mesalazine in humans and animals.
High-performance liquid chromatographic determination of ciprofloxacin in plasma samples.
TLDR
A new bioanalytical high-performance liquid chromatographic (HPLC) method for the determination of ciprofloxacin with norfloxACin as an internal standard was developed and validated for plasma samples and applied to pharmacokinetic studies.
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