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Role of Glutathione in Cancer Progression and Chemoresistance
Glutathione (GSH) plays an important role in a multitude of cellular processes, including cell differentiation, proliferation, and apoptosis, and disturbances in GSH homeostasis are involved in theExpand
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The Nrf2/HO-1 Axis in Cancer Cell Growth and Chemoresistance
The transcription factor, nuclear factor erythroid 2 p45-related factor 2 (Nrf2), acts as a sensor of oxidative or electrophilic stresses and plays a pivotal role in redox homeostasis. Oxidative orExpand
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Redox Homeostasis and Cellular Antioxidant Systems: Crucial Players in Cancer Growth and Therapy
Reactive oxygen species (ROS) and their products are components of cell signaling pathways and play important roles in cellular physiology and pathophysiology. Under physiological conditions, cellsExpand
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Signal pathway involved in the development of hypoxic preconditioning in rat hepatocytes
Ischemic preconditioning improves liver resistance to hypoxia and reduces reperfusion injury following transplantation. However, the intracellular signals that mediate the development of liverExpand
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Signal pathway responsible for hepatocyte preconditioning by nitric oxide.
Nitric oxide (NO) improves liver resistance to hypoxia/reperfusion injury acting as a mediator of hepatic preconditioning. However, the mechanisms involved are still poorly understood. In this study,Expand
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Heme Oxygenase 1 in the Nervous System: Does It Favor Neuronal Cell Survival or Induce Neurodegeneration?
Heme oxygenase 1 (HO-1) up-regulation is recognized as a pivotal mechanism of cell adaptation to stress. Under control of different transcription factors but with a prominent role played by Nrf2,Expand
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Metformin restores the mitochondrial network and reverses mitochondrial dysfunction in Down syndrome cells
Alterations in mitochondrial activity and morphology have been demonstrated in human cells and tissues from individuals with Down syndrome (DS), as well as in DS mouse models. An impaired activity ofExpand
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PKC delta and NADPH oxidase in AGE-induced neuronal death
Advanced glycation end product (AGE) accumulation in brain is believed to contribute to neuronal death in several neurodegenerative diseases. Neurons exposed to AGEs undergo oxidative stress, but theExpand
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PKC delta and NADPH oxidase in retinoic acid-induced neuroblastoma cell differentiation.
The role of reactive oxygen species (ROS) in the regulation of signal transduction processes has been well established in many cell types and recently the fine tuning of redox signalling in neuronsExpand
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Role of phosphatidylinositol 3-kinase in the development of hepatocyte preconditioning.
BACKGROUND & AIMS Ischemic preconditioning has been proved effective in reducing ischemia/reperfusion injury during liver surgery. However, the mechanisms involved are still poorly understood. Here,Expand
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