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IRF8 acts in lineage-committed rather than oligopotent progenitors to control neutrophil vs monocyte production.
Roles for IRF8 are identified in regulating progenitor survival and differentiation and preventing leukemic cell accumulation, which shows it does not regulate granulocytic vs monocytic fate in GMPs, but instead acts downstream of lineage commitment to selectively control neutrophil and monocyte production. Expand
Wnt/β-catenin signaling regulates proliferation of human cornea epithelial stem/progenitor cells.
These findings demonstrate for the first time that Wnt signaling is present in the ocular surface epithelium and plays an important role in the regulation of LSC proliferation. Expand
Detection of a TLR2 agonist by hematopoietic stem and progenitor cells impacts the function of the macrophages they produce
In vitro and in vivo studies show that macrophages derived from mouse and human HSPC subsets exposed to a TLR2 agonist prior to or during macrophage differentiation produce lower levels of inflammatory cytokines and reactive oxygen species, and this may impact the clinical utility of targeting TLRs on HSPCs to boost myelopoiesis. Expand
Preferential Biological Processes in the Human Limbus by Differential Gene Profiling
Gene ontology and network analysis of the overexpressed limbal genes revealed cell-cell adhesion, Wnt and TGF-β/BMP signaling components among other developmental processes in the limbus that could aid in a better understanding of the regulatory elements in the LSC microenvironment. Expand