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Large-Scale Simultaneous Hypothesis Testing: The Choice of a Null Hypothesis
- M. Newton
Approximate Bayesian-inference With the Weighted Likelihood Bootstrap
- M. Newton
We introduce the weighted likelihood bootstrap (WLB) as a way to simulate approximately from a posterior distribution. This method is often easy to implement, requiring only an algorithm for… Expand
Detecting differential gene expression with a semiparametric hierarchical mixture method.
Mixture modeling provides an effective approach to the differential expression problem in microarray data analysis. Methods based on fully parametric mixture models are available, but lack of fit in… Expand
Bayesian phylogenetic inference via Markov chain Monte Carlo methods.
We derive a Markov chain to sample from the posterior distribution for a phylogenetic tree given sequence information from the corresponding set of organisms, a stochastic model for these data, and a… Expand
On parametric empirical Bayes methods for comparing multiple groups using replicated gene expression profiles.
- C. Kendziorski, M. Newton, H. Lan, M. Gould
- Medicine, Computer Science
- Statistics in medicine
- 30 December 2003
DNA microarrays provide for unprecedented large-scale views of gene expression and, as a result, have emerged as a fundamental measurement tool in the study of diverse biological systems. Statistical… Expand
Fundamental differences in cell cycle deregulation in human papillomavirus-positive and human papillomavirus-negative head/neck and cervical cancers.
Human papillomaviruses (HPV) are associated with nearly all cervical cancers, 20% to 30% of head and neck cancers (HNC), and other cancers. Because HNCs also arise in HPV-negative patients, this type… Expand
Drosophila RNAi screen identifies host genes important for influenza virus replication
All viruses rely on host cell proteins and their associated mechanisms to complete the viral life cycle. Identifying the host molecules that participate in each step of virus replication could… Expand
Genetic identification of multiple loci that control breast cancer susceptibility in the rat.
We have used a rat model of induced mammary carcinomas in an effort to identify breast cancer susceptibility genes. Using genetic crosses between the carcinoma-resistant Copenhagen (COP) and… Expand
RANDOM-SET METHODS IDENTIFY DISTINCT ASPECTS OF THE ENRICHMENT SIGNAL IN GENE-SET ANALYSIS
A prespecified set of genes may be enriched, to varying degrees, for genes that have altered expression levels relative to two or more states of a cell. Knowing the enrichment of gene sets defined by… Expand
MicroRNA 29c is down-regulated in nasopharyngeal carcinomas, up-regulating mRNAs encoding extracellular matrix proteins
- Srikumar Sengupta, J. D. den Boon, +7 authors P. Ahlquist
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 15 April 2008
Using highly sensitive microarray-based procedures, we identified eight microRNAs (miRNAs) showing robust differential expression between 31 laser-capture-microdissected nasopharyngeal carcinomas… Expand