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Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
This study has demonstrated that careful use of a shared control group represents a safe and effective approach to GWA analyses of multiple disease phenotypes; generated a genome-wide genotype database for future studies of common diseases in the British population; and shown that, provided individuals with non-European ancestry are excluded, the extent of population stratification in theBritish population is generally modest. Expand
Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants
These findings, enabled in part by increased statistical power resulting from the expansion of the control reference group to include individuals from the other disease groups, highlight notable new possibilities for autoimmune regulation and suggest that IL23R may be a common susceptibility factor for the major 'seronegative' diseases. Expand
Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2
This study demonstrates that genome-wide association studies can identify new susceptibility loci for infectious diseases, even in African populations, in which levels of linkage disequilibrium are particularly low. Expand
Comparative high-resolution analysis of linkage disequilibrium and tag single nucleotide polymorphisms between populations in the vitamin D receptor gene.
Direct comparison indicates that the tag SNPs selected in one European population effectively predict the non-tag SNPs in the other Europeans, but not in the Gambians, for this region. Expand
Common variants at 11p13 are associated with susceptibility to tuberculosis
After imputation of data from the 1000 Genomes Project into a genome-wide dataset of Ghanaian individuals with tuberculosis and controls, we identified a resistance locus on chromosome 11p13Expand
Interferon-gamma-receptor deficiency in an infant with fatal bacille Calmette-Guérin infection.
The attenuated strain of Mycobacterium bovis bacille Calmette–Guerin (BCG) is the most widely used vaccine in the world. In most children, inoculation of live BCG vaccine is harmless although it oc...
Influence of Mycobacterium bovis Bacillus Calmette-Guérin on Antibody and Cytokine Responses to Human Neonatal Vaccination1
BCG influences the immune response to unrelated Ags in early life, likely through its influence on the maturation of dendritic cells, as it increased the Ab response to oral polio vaccine. Expand
Newborns develop a Th1-type immune response to Mycobacterium bovis bacillus Calmette-Guérin vaccination.
It is found that BCG vaccination at birth induces a memory Th1-type response of similar magnitude to that when given later in life. Expand
IFNGR1 gene promoter polymorphisms and susceptibility to cerebral malaria.
Case-control analysis of Gambian children with severe malaria and umbilical cord blood samples (controls) showed that in Mandinka, the major Gambian ethnic group, heterozygotes for the IFNGR1-56 polymorphism were protected against cerebral malaria and against death resulting from cerebral malaria. Expand
The toll-like receptor 4 Asp299Gly variant: no influence on LPS responsiveness or susceptibility to pulmonary tuberculosis in The Gambia.
The data suggest that TLR4 Asp299Gly has no influence on monocyte LPS responses or susceptibility to TB in Gambians and could be an ancient neutral polymorphism. Expand