Cytokines in inflammatory bowel disease
- M. Neurath
- Biology, MedicineNature reviews. Immunology
- 1 May 2014
The role of cytokines produced by innate and adaptive immune cells, as well as their relevance to the future therapy of IBD are discussed.
RAGE Mediates a Novel Proinflammatory Axis A Central Cell Surface Receptor for S100/Calgranulin Polypeptides
Chemically induced mouse models of intestinal inflammation
Animal models of intestinal inflammation are indispensable for our understanding of the pathogenesis of Crohn disease and ulcerative colitis, the two major forms of inflammatory bowel disease in…
IL-35-producing B cells are critical regulators of immunity during autoimmune and infectious diseases
The increased immunity found in mice lacking IL-35 production by B cells was associated with a higher activation of macrophages and inflammatory T cells, as well as an increased function of B cells as antigen-presenting cells (APCs).
Cutting Edge: TGF-β Induces a Regulatory Phenotype in CD4+CD25− T Cells through Foxp3 Induction and Down-Regulation of Smad7
- M. Fantini, C. Becker, G. Monteleone, F. Pallone, P. Galle, M. Neurath
- BiologyJournal of Immunology
- 1 May 2004
It is demonstrated that TGF-β induces a regulatory phenotype in CD4+CD25− T cells through the induction of Foxp3 and a positive autoregulatory loop of T GF-β signaling due to the absence of Smad7.
STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing
The data suggest that intestinal epithelial STAT3 activation regulates immune homeostasis in the gut by promoting IL-22–dependent mucosal wound healing and Gene chip analysis indicated that STAT3 regulates the cellular stress response, apoptosis, and pathways associated with wound healing in IECs.
Antibodies to interleukin 12 abrogate established experimental colitis in mice
- M. Neurath, I. Fuss, B. Kelsall, E. Stüber, W. Strober
- Biology, MedicineJournal of Experimental Medicine
- 1 November 1995
The data demonstrate the pivotal role of IL-12 and IFN-gamma in a TNBS-induced murine model of chronic intestinal inflammation and suggest the potential utility of anti-IL-12 antibodies in patients with Crohn's disease.
An inducible mouse model of colon carcinogenesis for the analysis of sporadic and inflammation-driven tumor progression
A highly reliable protocol is provided for an experimental mouse model to study the development of colon cancers based on the mutagenic agent azoxymethane (AOM), which exerts colonotropic carcinogenicity.
Epithelial NEMO links innate immunity to chronic intestinal inflammation
It is demonstrated that a primary NF-κB signalling defect in intestinal epithelial cells disrupts immune homeostasis in the gastrointestinal tract, causing an inflammatory-bowel-disease-like phenotype.
Local administration of antisense phosphorothiate olignucleotides to the p65 subunit of NF–κB abrogates established experimental colitis in mice
- M. Neurath, S. Pettersson, K. Z. Büschenfelde, W. Strober
- Biology, MedicineNature Network Boston
- 1 September 1996
Local administration of p65 antisense phosphorothioate oligonucleotides abrogated clinical and histological signs of colitis and was more effective in treating TNBS–induced colitis than single or daily administration of glucocorticoids.