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Electron microscopy and structural model of human fibronectin receptor.
Highly‐purified human fibronectin receptor (a heterodimer of two distinct subunits, alpha and beta) was studied using electron microscopy and a variety of preparative procedures. It was found that… Expand
Structural Analyses of Purified Human Immunodeficiency Virus Type 1 Intracellular Reverse Transcription Complexes
- M. Nermut, A. Fassati
- Biology, Medicine
- Journal of Virology
- 1 August 2003
ABSTRACT Retroviruses copy their RNA genome into a DNA molecule, but little is known of the structure of the complex mediating reverse transcription in vivo. We used confocal and electron microscopy… Expand
Cell/substratum adhesions in RSV-transformed rat fibroblasts.
Cell/substratum adhesions have been studied in rat fibroblasts transformed by a ts-mutant of Rous sarcoma virus (LA-29) using light and electron microscopy and a variety of preparative methods… Expand
Roles of Matrix, p2, and N-Terminal Myristoylation in Human Immunodeficiency Virus Type 1 Gag Assembly
- Y. Morikawa, D. Hockley, M. Nermut, I. Jones
- Biology, Medicine
- Journal of Virology
- 1 January 2000
ABSTRACT Human immunodeficiency virus type 1 Gag protein is cotranslationally myristoylated at the N terminus and targeted to the plasma membrane, where virus particle assembly occurs. Particle… Expand
Distinct signals in human immunodeficiency virus type 1 Pr55 necessary for RNA binding and particle formation.
- J. Jowett, D. Hockley, M. Nermut, I. Jones
- Biology, Medicine
- The Journal of general virology
- 1 December 1992
The human immunodeficiency virus type 1 (HIV-1) gag gene product Pr55 self-assembles to form virus-like particles when expressed in Spodoptera frugiperda cells using recombinant baculoviruses. The… Expand
Further evidence for hexagonal organization of HIV gag protein in prebudding assemblies and immature virus-like particles.
- M. Nermut, D. Hockley, P. Bron, D. Thomas, W. Zhang, I. Jones
- Chemistry, Medicine
- Journal of structural biology
- 1 October 1998
The fullerene-like model for the organization of HIV gag encoded precursor pr55gag was based on the study of prebudding assemblies at the plasma membrane of cells infected with a recombinant… Expand
Comparative morphology of Gag protein structures produced by mutants of the gag gene of human immunodeficiency virus type 1.
- D. Hockley, M. Nermut, C. Grief, J. Jowett, I. Jones
- Biology, Medicine
- The Journal of general virology
- 1 November 1994
Six mutants that differ in the extent of their carboxyterminal sequences and two deletion mutants of the gag gene of HIV-1 have been characterized morphologically following their expression in… Expand
Fullerene-like organization of HIV gag-protein shell in virus-like particles produced by recombinant baculovirus.
- M. Nermut, D. Hockley, J. Jowett, I. Jones, M. Garreau, D. Thomas
- Biology, Medicine
- Virology
- 1994
Virus-like particles produced by a recombinant baculovirus containing the HIV gag gene were examined by negative staining after delipidization. This technique demonstrated that the gag-protein shell… Expand
Evidence that the amantadine-induced, M2-mediated conversion of influenza A virus hemagglutinin to the low pH conformation occurs in an acidic trans Golgi compartment.
Amantadine treatment of cells infected with H7 strains of influenza A viruses causes an M2 protein-mediated conversion of hemagglutinin (HA) from its native to its low pH conformation.… Expand
Ultrastructure and gold-immunolabelling of cell-substratum adhesions (podosomes) in RSV-transformed BHK cells.
- I. Gavazzi, M. Nermut, P. Marchisio
- Biology, Medicine
- Journal of cell science
- 1 September 1989
Rous sarcoma virus-transformed BHK (RSV/B4-BHK) cells develop peculiar dot-like adhesions, that have been named podosomes, which, in the presence of serum, aggregate into ring- or crescent-shaped… Expand