M. Needham

Publications127
h-index27
Citations2,577
Highly Influential Citations88
Claim Author Page
Author pages are created from data sourced from our academic publisher partnerships and public sources.

Recommended Authors

  • P. Visscher
  • 761 Publications • 113,466 Citations
  • J. Veldink
  • 402 Publications • 25,908 Citations
  • N. Wray
  • 507 Publications • 59,193 Citations
  • A. Al-Chalabi
  • 451 Publications • 36,592 Citations
  • Publications
  • Influence
Inclusion body myositis: current pathogenetic concepts and diagnostic and therapeutic approaches
View on Elsevier
Use of Whole-Exome Sequencing for Diagnosis of Limb-Girdle Muscular Dystrophy: Outcomes and Lessons Learned.
TLDR
The central goals were to improve the genetic diagnosis of LGMD, investigate whether the WES platform provides adequate coverage of known LGMD-related genes, and identify new LGMD -related genes.
View on PubMed
Evaluation and construction of diagnostic criteria for inclusion body myositis
TLDR
This study provides Class II evidence that published expert consensus–derived IBM diagnostic categories accurately distinguish IBM from other muscle disease with high specificity but wide-ranging sensitivities.
View on Wolters Kluwer
Progressive myopathy with up-regulation of MHC-I associated with statin therapy
View on Elsevier
Statin myotoxicity: A review of genetic susceptibility factors
View on Elsevier
Mutations in HSPB8 causing a new phenotype of distal myopathy and motor neuropathy
TLDR
Patients can develop a myopathy with histologic features of myofibrillar myopathic with aggregates and rimmed vacuoles, similar to the pathology in myopathies due to gene defects in other compounds of the CASA complex such as BAG3 and DNAJB6 after developing the early neurogenic effects.
View on Publisher
Fibroblast growth factor 21 is a sensitive biomarker of mitochondrial disease
TLDR
This prospective study establishes serum FGF-21 levels as a sensitive biomarker of mitochondrial disease and demonstrates that they are the best predictor of this disorder when compared to serum levels of classical indicators: creatine kinase, lactate, pyruvate, and the lactate to pyruVate ratio.
View on Wolters Kluwer
Necrotizing autoimmune myopathy
TLDR
It is important to recognize and distinguish NAM from other causes of myocyte necrosis, because it has the potential of being amenable to treatment, and may provide a useful diagnostic test in the future, to help differentiate immune from nonimmune statin myopathies.
View on Wolters Kluwer
Polymorphism in the TOMM40 gene modifies the risk of developing sporadic inclusion body myositis and the age of onset of symptoms
View on Elsevier
Update on Toxic Myopathies
TLDR
The current update focuses on the mechanisms of statin myotoxicity and the importance of genetic predisposing factors for statinmyopathy, as well as the recently described form of necrotizing autoimmune myopathy, which is associated with antibodies to the 3-hydroxy-3-methylglutaryl-coenzyme A reductase enzyme and is responsive to aggressive immunotherapy.
View on Springer
...
...