• Publications
  • Influence
Genetic epidemiology of major depression: review and meta-analysis.
A meta-analysis of relevant data from primary studies of the genetic epidemiology of major depression suggested that familial aggregation was due to additive genetic effects, with a minimal contribution of environmental effects common to siblings and substantial individual-specific environmental effects/measurement error. Expand
OpenMx: An Open Source Extended Structural Equation Modeling Framework
The OpenMx data structures are introduced—these novel structures define the user interface framework and provide new opportunities for model specification and a discussion of directions for future development. Expand
Methodology for Genetic Studies of Twins and Families
Preface. List of Figures. List of Tables. 1. The Scope of Genetic Analyses. 2. Data Summary. 3. Biometrical Genetics. 4. Matrix Algebra. 5. Path Analysis and Structural Equations. 6. LISREL ModelsExpand
Genetic and Environmental Factors in Relative Body Weight and Human Adiposity
Data from the Virginia 30,000, including twins and their parents, siblings, spouses, and children, were analyzed using a structural equation model (Stealth) and no evidence was found for a special MZ twin environment, thereby supporting the equal environment assumption. Expand
The structure of genetic and environmental risk factors for common psychiatric and substance use disorders in men and women.
The underlying structure of the genetic and environmental risk factors for the common psychiatric and drug abuse disorders in men and women is very similar. Expand
A review and meta-analysis of the genetic epidemiology of anxiety disorders.
Meta-analyses of data from family and twin studies of panic disorder, generalized anxiety disorder, phobias, and obsessive-compulsive disorder revealed significant familial aggregation, underscoring the importance of identifying putative environmental risk factors that predispose individuals to anxiety. Expand
Distinct genetic influences on cortical surface area and cortical thickness.
It is demonstrated that cortical volume measures combine at least 2 distinct sources of genetic influences, and using volume in a genetically informative study, or as an endophenotype for a disorder, may confound the underlying genetic architecture of brain structure. Expand
Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis
The findings show that specific SNPs are associated with a range of psychiatric disorders of childhood onset or adult onset, and variation in calcium-channel activity genes seems to have pleiotropic effects on psychopathology. Expand
Schizophrenia as a complex trait: evidence from a meta-analysis of twin studies.
Despite evidence of heterogeneity across studies, meta-analytic results from 12 published twin studies of schizophrenia are consistent with a view of schizophrenia as a complex trait that results from genetic and environmental etiological influences. Expand
OpenMx 2.0: Extended Structural Equation and Statistical Modeling
Ease-of-use improvements include helper functions to standardize model parameters and compute their Jacobian-based standard errors, access to model components through standard R $ mechanisms, and improved tab completion from within the R Graphical User Interface. Expand