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Antimicrobial natural products: an update on future antibiotic drug candidates.
This review will describe only those with potentially useful antimicrobial activity, viz. with MICs in the range 0.02-10 microg mL(-1); a total of 145 compounds from 13 structural classes are discussed, and over 100 references are cited. Expand
Polyketide Skeletons from the Marine Alga‐Derived Fungus Coniothyrium cereale
The fungus Coniothyrium cereale was isolated from the Baltic Sea alga Enteromorpha sp. Upon cultivation in saline medium, C. cereale produced the structurally unprecedented isoindole pseudoalkaloidExpand
Phenalenones: insight into the biosynthesis of polyketides from the marine alga-derived fungus Coniothyrium cereale.
The polyketide skeleton of the phenanthrene-based compound cereolactam is proposed to be formed through degradation of a heptaketide by loss of two carbon atoms, thus providing a hypothesis for the biosynthetic formation of the Phenalenones. Expand
Phytochemical profiling, in vitro biological properties and in silico studies on Caragana ambigua stocks (Fabaceae): A comprehensive approach
Abstract Plant from Caragana genus have interesting potential in folklore medicines and have been explored for various pharmacological activities. The aim of this study was to probe into the chemicalExpand
New phthalates from Phyllanthus muellerianus (Euphorbiaceae)
This paper deals with the phytochemical investigation on Phyllanthus muellerianus and isolates 3–5 have been isolated and characterized for the first time from this source. Expand
GPR18 Inhibiting Amauromine and the Novel Triterpene Glycoside Auxarthonoside from the Sponge-Derived Fungus Auxarthron reticulatum.
The diketopiperazine 1 may serve as a lead structure for the development of more potent and selective GPR18 antagonists, which are required to study the orphan receptor's potential as a new drug target. Expand
Two New Antimicrobial Metabolites from the Endophytic Fungus, Seimatosporium sp
Two new acaranoic acids, named seimatoporic acid A and B, together with six known compounds, R-(-)-mellein, showed strong antifungal activity against Botrytis cinerea, Septoria tritici, and Pyricularia oryzae. Expand
Insights into the Biosynthetic Origin of 3-(3-Furyl)alanine in Stachylidium sp. 293 K04 Tetrapeptides.
The marine-sponge-derived fungus Stachylidium sp. 293 K04 produces the N-methylated peptides endolide A (1) and endolide B (2), showing affinity for the vasopressin receptor 1A and serotonin receptorExpand
Natural Phenolics as Inhibitors of the Human Neutrophil Elastase (HNE) Release: An Overview of Natural Anti-inflammatory Discoveries during Recent Years.
A review article summarizes the discovery and elastase inhibitory activity of ∼180 phenolics isolated from diverse natural sources during more than one decade, i.e. 2005-2017, to develop better anti-inflammatory drugs in future. Expand