Share This Author
Metabolism of methotrexate in man after high and conventional doses.
It is concluded that methotrexate is significantly metabolized in man at all doses used clinically.
Coumarins and other constituents of Hesperethusa crenulata
Isoprenylcoumarins from Boenninghausenia albiflora
Gas Chromatographic Analysis of Cyclophosphamide in Plasma and Tissues Using Nitrogen-Phosphorus Detection
Abstract A gas chromatographic method for the analysis of cyclophosphamide in plasma, blood, and organ tissues is described. This method involves extraction of aliquots of plasma or tissue…
Identification of metabolites of the cell-differentiating agent hexamethylene bisacetamide in humans.
Hexamethylene bisacetamide, a compound which in vitro induces differentiation in a wide variety of human and animal cancer cell lines, is being investigated in phase I clinical trials and metabolites identified included the major metabolite, 6-acetamidohexanoic acid.
Formylation of Secondary Amines with Dialkyl Acetals of Dimethylformamide
Abstract The product of the reaction of dialkyl acetals of N, N-dimethyl-formamide with desipramine has been found to be N-formyldesipramine, and not the N-ethyl derivative as reported earlier.…
Effects of pH and temperature on the stability and decomposition of N,N'N"-triethylenethiophosphoramide in urine and buffer.
Thiotepa degradation occurs by successive addition of HCl molecules with opening of the aziridine rings and conversion to 2-chloroethyl moieties and alkylating activity was stable at all temperatures and pHs tested.
Reversed-phase high-performance liquid chromatographic analysis of methotrexate and 7-hydroxymethotrexate in serum.
Alkaloids of the stem bark of Hesperethusa crenulata
Diaziquone given as a continuous infusion is an active agent for relapsed adult acute nonlymphocytic leukemia.
The lack of significant nonhematologic toxicity and the activity in patients with relapsed ANLL render diaziquone of interest as second-line therapy or consolidation therapy in first remission for patients with ANLL.