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Pathogenesis of Helicobacter pylori infection
Five years after publication of the complete genome sequence of Helicobacter pylori, research interest is shifting from the descriptive association of virulence factors with clinical outcome inExpand
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A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits
A novel protein complex has been identified in human cells that has a molecular mass of approximately 450 kDa. It consists of at least eight different subunits including JAB1, the JunExpand
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Helicobacter pylori CagA protein targets the c-Met receptor and enhances the motogenic response
Infection with the human microbial pathogen Helicobacter pylori is assumed to lead to invasive gastric cancer. We find that H. pylori activates the hepatocyte growth factor/scatter factor receptorExpand
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Fission yeast COP9/signalosome suppresses cullin activity through recruitment of the deubiquitylating enzyme Ubp12p.
The COP9/signalosome (CSN) is known to remove the stimulatory NEDD8 modification from cullins. The activity of the fission yeast cullins Pcu1p and Pcu3p is dramatically stimulated when retrieved fromExpand
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Encoding and Transducing the Synaptic or Extrasynaptic Origin of NMDA Receptor Signals to the Nucleus
The activation of N-methyl-D-aspartate-receptors (NMDARs) in synapses provides plasticity and cell survival signals, whereas NMDARs residing in the neuronal membrane outside synapses triggerExpand
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Activation of NF‐kappa B in vivo is regulated by multiple phosphorylations.
The activation of nuclear factor kappa B (NF‐kappa B) in intact cells is mechanistically not well understood. Therefore we investigated the modifications imposed on NF‐kappa B/I kappa B componentsExpand
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What a disorder: proinflammatory signaling pathways induced by Helicobacter pylori.
Infection of gastric epithelial cells with Helicobacter pylori induces strong proinflammatory responses by activating nuclear transcription factors NF-κB and AP-1. Several reports indicate thatExpand
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CSN controls NF-kappaB by deubiquitinylation of IkappaBalpha.
The COP9 signalosome (CSN) is a conserved protein complex that regulates assembly and activity of cullin-RING ubiquitin ligases (CRLs). Ubiquitin-dependent degradation of the NF-kappaB inhibitorExpand
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COP9 Signalosome-directed c-Jun Activation/Stabilization Is Independent of JNK*
The basic region-leucine zipper transcription factor c-Jun regulates gene expression and cell function. It participates in the formation of homo- or heterodimeric complexes that specifically bind toExpand
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Neisseria gonorrhoeae Epithelial Cell Interaction Leads to the Activation of the Transcription Factors Nuclear Factor κB and Activator Protein 1 and the Induction of Inflammatory Cytokines
We have studied the effect of human bacterial pathogen Neisseria gonorrhoeae (Ngo) on the activation of nuclear factor (NF)-κB and the transcriptional activation of inflammatory cytokine genes uponExpand
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