• Publications
  • Influence
Electromechanical model of excitable tissue to study reentrant cardiac arrhythmias.
  • M. Nash, A. Panfilov
  • Physics, Medicine
    Progress in biophysics and molecular biology
  • 1 June 2004
TLDR
It is shown that tissue mechanics significantly contributes to the dynamics of electrical propagation, and that a coupled electromechanical approach should be pursued in future electrophysiological modelling studies.
Computational Mechanics of the Heart
Finite elasticity theory combined with finite element analysis provides the framework for analysing ventricular mechanics during the filling phase of the cardiac cycle, when cardiac cells are not
Modelling passive diastolic mechanics with quantitative MRI of cardiac structure and function
TLDR
Simulation of diastolic LV mechanics allowed us to estimate the stiffness of the passive LV myocardium based on kinematic data obtained from tagged MRI, thereby improving the understanding of the underlying structural basis of mechanical dysfunction under pathological conditions.
Whole heart action potential duration restitution properties in cardiac patients: a combined clinical and modelling study
TLDR
A simplified computer model of 2‐D cardiac tissue was used to investigate how heterogeneous APD restitution can influence vulnerability to, and stability of re‐entry, and showed that heterogeneity of restitution can act as a potent arrhythmogenic substrate, as well as influencing the stability ofRe‐entrant arrhythias.
Self-organized pacemakers in a coupled reaction-diffusion-mechanics system.
TLDR
It is found that mechanical deformation can induce automatic pacemaking activity and it is shown that self-organized pacemakers drift throughout the medium to approach attractors with locations that depend on the size of the medium, and on the location of the initial stimulus.
Computational mechanics of the heart : From tissue structure to ventricular function
Finite elasticity theory combined with finite element analysis provides the framework for analysing ventricular mechanics during the filling phase of the cardiac cycle, when cardiac cells are not
Evidence for Multiple Mechanisms in Human Ventricular Fibrillation
TLDR
Electrical activity from the entire ventricular epicardium of human hearts is mapped to establish the relative roles of the mother rotor and multiple wavelet mechanisms of VF, which do not appear to be mutually exclusive in the human heart.
Phase Mapping of Cardiac Fibrillation
TLDR
The development of this phase mapping tool has led to better understanding of fibrillation dynamics as evidenced by the development of the state-space encoding concept from nonlinear dynamics.
Estimating material parameters of a structurally based constitutive relation for skin mechanics
TLDR
It was concluded that the objective function was highly sensitive to the mean orientation and that a priori information about fiber orientation mean was important for the reliable identification of constitutive parameters.
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