• Publications
  • Influence
Electromechanical model of excitable tissue to study reentrant cardiac arrhythmias.
  • M. Nash, A. Panfilov
  • Physics, Medicine
  • Progress in biophysics and molecular biology
  • 1 June 2004
We introduce the concept of a contracting excitable medium that is capable of conducting non-linear waves of excitation that in turn initiate contraction. Furthermore, these kinematic deformationsExpand
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Computational Mechanics of the Heart
Finite elasticity theory combined with finite element analysis provides the framework for analysing ventricular mechanics during the filling phase of the cardiac cycle, when cardiac cells are notExpand
  • 239
  • 13
Modelling passive diastolic mechanics with quantitative MRI of cardiac structure and function
TLDR
In order to better understand passive ventricular mechanics, a LV finite element (FE) model was customized to geometric data segmented from in vivo tagged magnetic resonance images (MRI) data and myofibre orientation derived from ex vivo diffusion tensor MRI of a canine heart using nonlinear finite element fitting techniques. Expand
  • 151
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Whole heart action potential duration restitution properties in cardiac patients: a combined clinical and modelling study
Steep action potential duration (APD) restitution has been shown to facilitate wavebreak and ventricular fibrillation. The global APD restitution properties in cardiac patients are unknown. We reportExpand
  • 141
  • 13
Self-organized pacemakers in a coupled reaction-diffusion-mechanics system.
Using a computational model of a coupled reaction-diffusion-mechanics system, we find that mechanical deformation can induce automatic pacemaking activity. Pacemaking is shown to occur after a singleExpand
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Computational mechanics of the heart : From tissue structure to ventricular function
Finite elasticity theory combined with finite element analysis provides the framework for analysing ventricular mechanics during the filling phase of the cardiac cycle, when cardiac cells are notExpand
  • 257
  • 8
Phase Mapping of Cardiac Fibrillation
Received January 25, 2009; accepted October 6, 2009. Phase is a descriptor that tracks the progression of a defined region of myocardium through the action potential and has been demonstrated to beExpand
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Evidence for Multiple Mechanisms in Human Ventricular Fibrillation
Background— The mechanisms that sustain ventricular fibrillation (VF) in the human heart remain unclear. Experimental models have demonstrated either a periodic source (mother rotor) or multipleExpand
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Estimating material parameters of a structurally based constitutive relation for skin mechanics
This paper presents a structurally based modeling framework to characterize the structure–function relation in skin tissues, based upon biaxial tensile experiments performed in vitro on porcine skin.Expand
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