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Application of computer-assisted sperm analysis system to elucidate lack of effects of cyclophosphamide on rat epididymal sperm motion.
TLDR
It was found that damaged spermatozoa could exhibit no changes on their motion when the damage was confined to the nuclei, and that the effect of CP on sperm nuclei was reversible. Expand
Collaborative assessment of optimal administration period and parameters to detect effects on male fertility in the rat: effects of cyclophosphamide on the male reproductive system.
TLDR
The results suggest that a fertility study with females is needed particularly in the case of mutagenic agents, together with a detailed histopathological evaluation for reliable detection of toxicity on the male reproductive system. Expand
Mechanism of Developmental Effects in Rats Caused by an N-Phenylimide Herbicide: Transient Fetal Anemia and Sequelae during Mid-to-Late Gestation.
TLDR
Developmental toxicity results from PPO inhibition in primitive erythroblasts, causing transient fetal anemia followed by death, and inhibition of PPO in rats, rabbits, and humans by the herbicides in vitro is proposed. Expand
Dermal developmental toxicity of N-phenylimide herbicides in rats.
TLDR
Dermal exposure of rats to S-53482 and S-23121 produced patterns of developmental toxicity similar to those resulting from oral exposure as well as teratogenic when administered dermally to pregnant rats as were the compounds administered orally. Expand
Evaluation of Recovery from Cyclophosphamide Testicular Toxicity in Rats
TLDR
It is suggested that histopathological changes as subtle as decreased number of spermatogonia should be detected in evaluations of male chemical reproductive toxicity and PCNA staining may be useful for predicting reversibility of testicular toxicity. Expand
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