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Lipopolysaccharides (LPS) of Oral Black-Pigmented Bacteria Induce Tumor Necrosis Factor Production by LPS-Refractory C3H/HeJ Macrophages in a Way Different from That of Salmonella LPS
Findings indicate that the active molecule(s) and mode of action of LPS from P. gingivalisand P. intermedia are quite different from those of L PS from Salmonella, and oral bacterial LPS preparations were comparatively resistant to polymyxin B treatment. Expand
Isolation of two toxic heptapeptide microcystins from an axenic strain of Microcystis aeruginosa, K-139.
Two toxic heptapeptides were isolated from an axenic Microcystis aeruginosa strain, K-139. Using mainly a non-destructive NMR method, we determined the structure of the major toxin to beExpand
Structural requirements of taxoids for nitric oxide and tumor necrosis factor production by murine macrophages.
The structure-activity relationship study found that the benzoyl group at the C-3' position of paclitaxel is the most important site to activate C3H/HeN M phi, and suggests that the binding of taxoid/LPS to tubulin is not essential for the Mphi activation. Expand
CD14 is not involved in Rhodobacter sphaeroides diphosphoryl lipid A inhibition of tumor necrosis factor alpha and nitric oxide induction by taxol in murine macrophages
Although the binding studies failed to examine cross competition for binding to macrophages, a possible explanation of these results is that LPS, RsDPLA, and taxol share the same molecule(s) on murine macrophage for their functional receptor(s), which is neither CD14 nor tubulin. Expand
Influence of Oligodeoxyribonucleotides on Early Events in Antibody Formation.∗
  • W. Braun, M. Nakano
  • Biology, Medicine
  • Proceedings of the Society for Experimental…
  • 1 July 1965
Summary The number of hemolysin-forming cells, assayed by Jerne's technique in spleens removed from AKR mice, 48 hours after immunization with heterologous red cells, is significantly higher whenExpand
Toxicity of Microcystis species isolated from natural blooms and purification of the toxin
The main target of the toxin in mice was the liver, and marked congestion and necrosis in the parenchymal cells around the central veins of the liver were observed microscopically in specimens that had been prepared from the mice with acute toxicity after injection with the toxin. Expand
Neutralization of microcystin shock in mice by tumor necrosis factor alpha antiserum
Findings indicate the involvement of TNF in microcystin shock and suggest a previous injection of rabbit anti-murine TNF-alpha serum could prevent the liver damage to some extent and protect the mice from death. Expand
Structural significance of the benzoyl group at the C-3'-N position of paclitaxel for nitric oxide and tumor necrosis factor production by murine macrophages.
Synthetic analogs of paclitaxel with replacement of the C-3'-N position found that the p-substitution of the benzoyl group definitely affects the activity to activate C3H/HeN M phi, and the analogs having a methyl or chloro group at thep-position exhibit stronger activity than that of pac litaxel. Expand
Microtubule-disrupting agents inhibit nitric oxide production in murine peritoneal macrophages stimulated with lipopolysaccharide or paclitaxel (Taxol)
It is suggested that microtubules function in the posttranscriptional processes of iNOS protein expression rather than in the transcriptional process ofiNOS mRNA and the synthetic process of NO molecules. Expand
Onapristone (ZK299) blocks the suppressive effect of progesterone, but not that of dexamethasone, on inducible nitric oxide synthase gene expression and nitric oxide production in murine macrophages.
The findings indicate that the inhibitory effect of progesterone occurs at least on the level of iNOS protein expression in the signaling pathway after the LPS-stimulus, and may suggest the existence of a yet unknown type of progestersone-receptor in murine macrophages. Expand