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Patent foramen ovale: current pathology, pathophysiology, and clinical status.
- H. Hara, R. Virmani, +8 authors R. Schwartz
- Journal of the American College of Cardiology
- 1 November 2005
Patent foramen ovale (PFO) is experiencing increased clinical interest as a congenital cardiac lesion persisting into adulthood. It is implicated in several serious clinical syndromes, including… Expand
The reconstituted 'humanized liver' in TK-NOG mice is mature and functional.
- M. Hasegawa, K. Kawai, +8 authors H. Suemizu
- Biology, Medicine
- Biochemical and biophysical research…
- 18 February 2011
To overcome the limitations of existing models, we developed a novel experimental in vivo platform for replacing mouse liver with functioning human liver tissue. To do this, a herpes simplex virus… Expand
Efficacy and safety of adjusted-dose prasugrel compared with clopidogrel in Japanese patients with acute coronary syndrome: the PRASFIT-ACS study.
- S. Saito, T. Isshiki, +8 authors M. Nakamura
- Circulation journal : official journal of the…
BACKGROUND Prasugrel is an antiplatelet agent that shows more prompt, potent, and consistent platelet inhibition than clopidogrel. The objective of this study was to confirm the efficacy and safety… Expand
Leucovorin, fluorouracil, and oxaliplatin plus bevacizumab versus S-1 and oxaliplatin plus bevacizumab in patients with metastatic colorectal cancer (SOFT): an open-label, non-inferiority, randomised…
BACKGROUND Studies done in Asia have shown that a regimen of S-1 plus oxaliplatin (SOX) has promising efficacy and safety in patients with metastatic colorectal cancer. We aimed to establish whether… Expand
Patterns and clinicopathologic features of extrahepatic recurrence of hepatocellular carcinoma after curative resection.
BACKGROUND Little is known about the metastatic pattern in patients with extrahepatic metastasis after the removal of primary hepatocellular carcinoma (HCC). The aim of the present study was to… Expand
Neuropilin 1 and neuropilin 2 co‐expression is significantly correlated with increased vascularity and poor prognosis in nonsmall cell lung carcinoma
Cell‐retained isoforms of vascular endothelial growth factor A (VEGF‐A) have been reported to play an essential role in tumor progression through stromal neovascularization in malignant solid tumors.… Expand
Expression pattern of vascular endothelial growth factor isoform is closely correlated with tumour stage and vascularisation in renal cell carcinoma.
Vascular endothelial growth factor (VEGF) has five isoforms (VEGF206, 189, 165, 145 and 121). Increased VEGF expression in renal cell carcinoma (RCC) is associated with angiogenesis, but, it is not… Expand
Epidermal growth factor receptor expression in human pancreatic cancer: Significance for liver metastasis.
- K. Tobita, H. Kijima, +9 authors H. Makuuchi
- Biology, Medicine
- International journal of molecular medicine
- 1 March 2003
Pancreatic cancer is a malignant tumor with an extremely poor prognosis. The mechanisms of the aggressive growth and metastasis are not yet extensively understood. Over-expression of epidermal growth… Expand
Expression pattern of angiogenic factors and prognosis after hepatic resection in hepatocellular carcinoma: importance of angiopoietin‐2 and hypoxia‐induced factor‐1a
- H. Wada, H. Nagano, +17 authors M. Monden
- Liver international : official journal of the…
- 1 May 2006
Abstract: Background: Hepatocellular carcinoma (HCC) is a hypervascular tumor and angiogenesis plays an important role in its progression. Angiogenesis is regulated by a balance between pro and… Expand
Safety and feasibility of an intravascular optical coherence tomography image wire system in the clinical setting.
- T. Yamaguchi, M. Terashima, +10 authors T. Suzuki
- The American journal of cardiology
- 1 March 2008
Optical coherence tomography (OCT) is a fiber-optic technology that enables high-resolution intracoronary imaging. The aim of this study was to evaluate the safety and feasibility of intracoronary… Expand