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Globomycin, a new peptide antibiotic with spheroplast-forming activity. II. Isolation and physico-chemical and biological characterization.
- M. Inukai, M. Nakajima, M. Osawa, T. Haneishi, M. Arai
- Biology, ChemistryJournal of antibiotics (Tokyo. )
- 1 May 1978
Formation of spheroplasts was observed when Escherichia coli was grown in the presence of globomycin, indicating inhibition of the bacterial cell wall synthesis as its mode of action.
Globomycin, a new peptide antibiotic with spheroplast-forming activity. III. Structural determination of globomycin.
The structure of globomycin has been determined by mass, PMR and CMR spectra and by chemical degradation and a newly developed mass analysis has been introduced for determining the diastereoisomers of allo-threonine.
Hydantocidin: a new compound with herbicidal activity from Streptomyces hygroscopicus.
Hydantocidin, a new compound with potent non-selective herbicidal activity, was found in a submerged culture of Streptomyces hygroscopicus SANK 63584 and has a unique structure with a spiro-bond between ribose and hydantoin moieties in the molecule.
Effects of Trehazolin, a Potent Trehalase Inhibitor, on Bombyx mori and Plant Pathogenic Fungi
TRZ inhibited trehalase of Rhizoctonia solani, a plant pathogenic fungus, with an IC50 value of 66 nM and showed insecticidal activity toward silkworms by injecting 50 to 100 μg.
Cornexistin: a new fungal metabolite with herbicidal activity.
Based on its herbicidal characteristics cornexistin may be classified as a postemergence herbicide active against certain young annual and perennial monocotyledonous and dicotylingonous plants with selective protection for corn.
Trehazolin, a slow, tight-binding inhibitor of silkworm trehalase.
Ogipeptins, novel inhibitors of LPS: physicochemical properties and structural elucidation
In the course of our screening program for inhibitors of lipopolysaccharide binding to cellular receptor CD14, a potent inhibitory activity was detected in the cultured broth of Pseudoalteromonas sp.…
Pedopeptins, novel inhibitors of LPS: Taxonomy of producing organism, fermentation, isolation, physicochemical properties and structural elucidation
- Yuki Hirota-takahata, Shiho Kozuma, Nahoki Kuraya, Daisuke Fukuda, M. Nakajima, O. Ando
- ChemistryJournal of antibiotics (Tokyo. )
- 1 March 2014
Three active compounds, pedopeptin A, B and C, were isolated from the broth and their structures were elucidated by physicochemical and spectral data to be new cyclic depsipeptides.
Mycoplanecins, novel antimycobacterial antibiotics from Actinoplanes awajinensis subsp. mycoplanecinus subsp. nov. I. Taxonomy of producing organism and fermentation.
From its morphological, cultural and physiological characteristics, this strain was determined to be a new subspecies of Actinoplanes awaj inensis and designated as A. awajinensis subsp.