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Endothelin generating pathway through endothelin1–31 in human cultured bronchial smooth muscle cells
The effects of endothelin (ET)‐11–31 and ET‐21–31, human chymase products of the corresponding big ETs, on the intracellular free Ca2+ concentration ([Ca2+]i) and [125I]‐ET‐1 binding wereExpand
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Na(+)influx via Na(+)/H(+)exchange activates protein kinase C isozymes delta and epsilon in cultured neonatal rat cardiac myocytes.
Protein kinase C (PKC) is one of the important signaling molecules in the development of the cardiac hypertrophic response, and activation of Na(+)/H(+)exchange is caused by PKC in myocytes. In thisExpand
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ICAM-1 expression on cardiac myocytes and aortic endothelial cells via their specific endothelin receptor subtype.
Endothelin-1 (ET-1) and Endothelin-3 (ET-3) increased the expression of intercellular adhesion molecule-1 (ICAM-1) on rat neonatal cultured cardiac myocytes and rat aortic endothelial cells.Expand
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Na+Influx via Na+/H+Exchange Activates Protein Kinase C Isozymesδ and ϵ in Cultured Neonatal Rat Cardiac Myocytes
Abstract Protein kinase C (PKC) is one of the important signaling molecules in the development of the cardiac hypertrophic response, and activation of Na + /H + exchange is caused by PKC in myocytes.Expand
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Total synthesis of human chymase inhibitor methyllinderone and structure--activity relationships of its derivatives.
Total synthesis of human chymase inhibitor methyllinderone has been achieved in only four steps with an overall yield of 21% from dimethyl squarate. We developed an efficient synthetic method forExpand
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Normalization of retinal vascular permeability in experimental diabetes with genistein.
PURPOSE To study the effects of genistein, a tyrosine kinase inhibitor, on retinal vascular permeability in an experimental diabetic rat model. METHODS Seventy-two rats were equally divided intoExpand
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Analysis of circadian blood pressure rhythm and target-organ damage in stroke-prone spontaneously hypertensive rats.
OBJECTIVE We compared diurnal patterns of blood pressure in Wistar-Kyoto (WKY) rats, spontaneously hypertensive rats (SHR) and stroke-prone spontaneously hypertensive rats (SHRSP), and analyzed theExpand
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Design, synthesis and pharmacological evaluation of 3-benzylazetidine-2-one-based human chymase inhibitors.
3-Benzylazetidine-2-one derivatives were designed and evaluated as a novel series of chymase inhibitors. Structure-activity relationship studies of 3-benzylazetidine-2-ones led to compounds 23, whichExpand
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The effects of chronic treatment with losartan, an angiotensin II type 1 (AT1) receptor antagonist, and benazepril, an angiotensin converting enzyme (ACE) inhibitor, on target-organ damage andExpand
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Endothelin receptor subtype antagonist activity of S-0139 in various isolated rabbit and canine arteries.
Vascular responses to endothelin peptides have been proposed to be mainly mediated via subtypes of the endothelin receptor, endothelin ET(A1), endothelin ET(B1), and endothelin ET(B2). The antagonistExpand
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