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Native umbilical cord matrix stem cells express hepatic markers and differentiate into hepatocyte-like cells.
TLDR
It is concluded that UCMSCs, with a newly demonstrated endodermic differentiation potential, might be an alternative source for liver-directed cell therapies. Expand
A role for autophagy during hepatic stellate cell activation.
TLDR
The demonstration of partly inhibition of in vitro HSC activation after treatment with an autophagy inhibitor unveils a potential new therapeutic strategy for liver fibrosis. Expand
Human skin fibroblasts: From mesodermal to hepatocyte‐like differentiation
TLDR
This work demonstrates that human skin fibroblasts are able to display mesodermal and endodermal differentiation capacities and provides arguments that these cells share MSCs features both on the phenotypic and functional levels. Expand
Sustained engraftment and tissue enzyme activity after liver cell transplantation for argininosuccinate lyase deficiency.
TLDR
Liver cell transplantation can achieve donor cell engraftment in humans in a significant proportion, leading to sustained metabolic and clinical control with psychomotor catch-up, changing the clinical phenotype from a severe neonatal one to a moderate late-onset type. Expand
Modulation of the neuronal dopamine transporter activity by the metabotropic glutamate receptor mGluR5 in rat striatal synaptosomes through phosphorylation mediated processes
TLDR
It is proposed that striatal mGluR5 contribute to the control of the DAT activity through concomitant activation of both protein kinase C and calcium calmodulin‐dependentprotein kinase II. Expand
Generation of Hepatic Stellate Cells from Human Pluripotent Stem Cells Enables In Vitro Modeling of Liver Fibrosis.
TLDR
Efficient differentiation of human pluripotent stem cells into HSC-like cells (iPSC-HSCs) is reported, which provides a robust in-vitro system for studying HSC development, modeling liver fibrosis, and drug toxicity screening. Expand
Connecting Mitochondria, Metabolism, and Stem Cell Fate
TLDR
How mitochondrial biogenesis, dynamics, and function are directly involved in embryonic and SSC differentiation and how metabolic and sensing pathways connect mitochondria and metabolism with cell fate and pluripotency are reviewed. Expand
Molecular and functional characterisation of glutamate transporters in rat cortical astrocytes exposed to a defined combination of growth factors during in vitro differentiation
TLDR
Data indicate that the addition of this classical combination of growth factors and nutriments drives the rapid differentiation toward a homogenous culture of fibrous astrocytes expressing functional glutamate transporters. Expand
Cryopreserved Liver Cell Transplantation Controls Ornithine Transcarbamylase Deficient Patient While Awaiting Liver Transplantation
TLDR
It is concluded that use of cryopreserved cells allowed short‐ to medium‐term metabolic control and urea synthesis in this male OTC‐deficient patient while waiting for OLT. Expand
Acute up‐regulation of glutamate uptake mediated by mGluR5a in reactive astrocytes
TLDR
It is concluded that mGluR5a contributes to a dynamic control of GLT‐1 function in activated astrocytes, acting as a glial sensor of the extracellular glutamate concentration in order to acutely regulate the excitatory transmission. Expand
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