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Identification of Splenic Reservoir Monocytes and Their Deployment to Inflammatory Sites
Monitoring Monocyte Reservoirs Monocytes are cells of the immune system that are recruited to sites of tissue injury and inflammation where they help to resolve the infection and are important forExpand
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The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions
Healing of myocardial infarction (MI) requires monocytes/macrophages. These mononuclear phagocytes likely degrade released macromolecules and aid in scavenging of dead cardiomyocytes, while mediatingExpand
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The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions
Nahrendorf et al. 2007. J. Exp. Med. doi:10.1084/jem.20070885 [OpenUrl][1][Abstract/FREE Full Text][2] [1]:Expand
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Myocardial infarction accelerates atherosclerosis
During progression of atherosclerosis, myeloid cells destabilize lipid-rich plaques in the arterial wall and cause their rupture, thus triggering myocardial infarction and stroke. Survivors of acuteExpand
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Origins of tumor-associated macrophages and neutrophils
Tumor-associated macrophages (TAMs) and tumor-associated neutrophils (TANs) can control cancer growth and exist in almost all solid neoplasms. The cells are known to descend from immature monocyticExpand
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Monocytes: protagonists of infarct inflammation and repair after myocardial infarction.
Myocardial infarction (MI) is the most frequent cause of heart failure, which is an incapacitating disease with high prevalence and broad socioeconomic impact. In 2008 in the United States, 5.7Expand
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Chronic variable stress activates hematopoietic stem cells
Exposure to psychosocial stress is a risk factor for many diseases, including atherosclerosis. Although incompletely understood, interaction between the psyche and the immune system provides oneExpand
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Local proliferation dominates lesional macrophage accumulation in atherosclerosis
During the inflammatory response that drives atherogenesis, macrophages accumulate progressively in the expanding arterial wall. The observation that circulating monocytes give rise to lesionalExpand
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Innate Response Activator B Cells Protect Against Microbial Sepsis
Immune Sentinels A classic paradigm in immunology holds that the immune response occurs in two waves: Rapidly responding cells of the innate immune system help to contain the invading pathogen andExpand
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Noninvasive Vascular Cell Adhesion Molecule-1 Imaging Identifies Inflammatory Activation of Cells in Atherosclerosis
Background— Noninvasive imaging of adhesion molecules such as vascular cell adhesion molecule-1 (VCAM-1) may identify early stages of inflammation in atherosclerosis. We hypothesized that a novel,Expand
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