• Publications
  • Influence
Thymoquinone protects against carbon tetrachloride hetatotoxicity in mice via an antioxidant mechanism
Thymoquinone (TQ) is the major active component of the volatile oil of Nigella sativa seeds. The effects of TQ on carbon tetrachloride (CC14)‐induced hepatotoxicity was investigated in male SwissExpand
  • 228
  • 10
Effects of thymoquinone on antioxidant enzyme activities, lipid peroxidation and DT‐diaphorase in different tissues of mice: a possible mechanism of action
The present investigation focused, firstly, on the effects of oral administration of thymoquinone (TQ) on antioxidant enzyme activities, lipid peroxidation and DT‐diaphorase activity in hepatic,Expand
  • 270
  • 10
Neuroprotective effects of thymoquinone against transient forebrain ischemia in the rat hippocampus.
Increasing evidence demonstrates that oxidative stress plays an important role in brain injury in experimental models of brain ischemia. Thymoquinone, the main constituents of the volatile oil fromExpand
  • 179
  • 9
  • PDF
Thymoquinone attenuates diethylnitrosamine induction of hepatic carcinogenesis through antioxidant signaling
Hepatocellular carcinoma accounts for about 80–90% of all liver cancer and is the fourth most common cause of cancer mortality. Although there are many strategies for the treatment of liver cancer,Expand
  • 122
  • 9
  • PDF
Protective effect of aminoguanidine against nephrotoxicity induced by cisplatin in normal rats.
The effect of aminoguanidine (AG) on nephrotoxicity induced by cisplatin (CDDP) was investigated. A single dose of CDDP (7.5 mg/kg i.p.) induced nephrotoxicity, manifested biochemically by aExpand
  • 75
  • 8
Protective effect of thymoquinone against doxorubicin-induced cardiotoxicity in rats: a possible mechanism of protection.
Administration of thymoquinone (10 mg kg(-1)day(-1), p.o.) with drinking water starting 5 days before a single injection of doxorubicin (15 mg kg(-1)i.p.) and continuing during the experimentalExpand
  • 281
  • 7
  • PDF
Thymoquinone ameliorates the nephrotoxicity induced by cisplatin in rodents and potentiates its antitumor activity.
The effects of thymoquinone (TQ) on cisplatin-induced nephrotoxicity in mice and rats were studied. Oral administration of TQ (50 mg/L in drinking water) for 5 days before and 5 days after singleExpand
  • 192
  • 7
Thymoquinone supplementation attenuates hypertension and renal damage in nitric oxide deficient hypertensive rats
The present study was undertaken to evaluate the protective effect of thymoquinone (TQ), the main constituent of the volatile oil from Nigella sativa seeds, in rats after chronic inhibition of nitricExpand
  • 97
  • 7
  • PDF
Acute and subchronic toxicity of thymoquinone in mice
The effects of acute and subchronic administration of thymoquinone (TQ), the main constituent of the volatile oil of the black seeds Nigella sativa, with significant cytoprotective properties, wereExpand
  • 110
  • 6
Thymoquinone supplementation induces quinone reductase and glutathione transferase in mice liver: possible role in protection against chemical carcinogenesis and toxicity
Thymoquinone (TQ), the main constituents of the volatile oil from Nigella sativa seeds is reported to protect laboratory animals against chemical carcinogenesis and toxicity through mechanism(s) thatExpand
  • 91
  • 6