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Role of cytokines as a double-edged sword in sepsis.
A decrease in IL-6 was associated with a better prognosis and overproduction of IL-10 was found to be the main predictor of severity and fatal outcome, indicating pro-inflammatory and anti-inflammatory cytokines constitute a double-edged sword in sepsis.
Cannabinoids as novel anti-inflammatory drugs.
- P. Nagarkatti, Rupal Pandey, S. Rieder, V. Hegde, M. Nagarkatti
- BiologyFuture medicinal chemistry
- 21 October 2009
This review will focus on the potential use of cannabinoids as a new class of anti-inflammatory agents against a number of inflammatory and autoimmune diseases that are primarily triggered by activated T cells or other cellular immune components.
Cannabidiol-Induced Apoptosis in Human Leukemia Cells: A Novel Role of Cannabidiol in the Regulation of p22phox and Nox4 Expression
- R. Mckallip, W. Jia, J. Schlomer, J. Warren, P. Nagarkatti, M. Nagarkatti
- BiologyMolecular Pharmacology
- 15 April 2006
The results from this study reveal that cannabidiol, acting through CB2 and regulation of Nox4 and p22phox expression, may be a novel and highly selective treatment for leukemia.
Bryostatin Modulates Latent HIV-1 Infection via PKC and AMPK Signaling but Inhibits Acute Infection in a Receptor Independent Manner
The dual role of bryostatin on HIV life cycle may be a beneficial adjunct to the treatment of HIV especially by purging latent virus from different cellular reservoirs such as brain and lymphoid organs.
Delta-9-tetrahydrocannabinol enhances breast cancer growth and metastasis by suppression of the antitumor immune response.
It is demonstrated that the human breast cancer cell lines MCF-7 and MDA-MB-231 and the mouse mammary carcinoma 4T1 express low to undetectable levels of cannabinoid receptors, CB1 and CB2, and that these cells are resistant to Delta9-THC-induced cytotoxicity.
Targeting CB2 cannabinoid receptors as a novel therapy to treat malignant lymphoblastic disease.
The current data demonstrate that CB2 cannabinoid receptors expressed on malignancies of the immune system may serve as potential targets for the induction of apoptosis, and because CB2 agonists lack psychotropic effects, they may Serve as novel anticancer agents to selectively target and kill tumors of immune origin.
Cannabinoid-induced apoptosis in immune cells as a pathway to immunosuppression.
Resveratrol Suppresses Colitis and Colon Cancer Associated with Colitis
It is indicated that resveratrol is a useful, nontoxic complementary and alternative strategy to abate colitis and potentially colon cancer associated with colitis.
Activation of Aryl Hydrocarbon Receptor (AhR) Leads to Reciprocal Epigenetic Regulation of FoxP3 and IL-17 Expression and Amelioration of Experimental Colitis
- Narendra P. Singh, U. Singh, Balwan Singh, R. Price, M. Nagarkatti, P. Nagarkatti
- Biology, MedicinePloS one
- 15 August 2011
These studies demonstrate for the first time that AhR activation promotes epigenetic regulation thereby influencing reciprocal differentiation of Tregs and Th17 cells, and amelioration of inflammation.
Activation through Cannabinoid Receptors 1 and 2 on Dendritic Cells Triggers NF-κB-Dependent Apoptosis: Novel Role for Endogenous and Exogenous Cannabinoids in Immunoregulation1
- Y. Do, R. Mckallip, M. Nagarkatti, P. Nagarkatti
- Biology, ChemistryThe Journal of Immunology
- 15 August 2004
It is demonstrated for the first time that endogenous and exogenous cannabinoids may suppress the immune response through their ability to induce apoptosis in DCs.