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Extraction of a plasma time-activity curve from dynamic brain PET images based on independent component analysis
TLDR
The results demonstrated that EPICA is useful for extracting the pTAC from dynamic PET images without the necessity of serial arterial blood sampling, and that the estimated blood volume image was highly correlated with the bloodvolume image measured using /sup 15/O-CO inhalation.
Assessing Synaptic Density in Alzheimer Disease With Synaptic Vesicle Glycoprotein 2A Positron Emission Tomographic Imaging
TLDR
This approach may provide a direct measure of synaptic density, and it therefore holds promise as an in vivo biomarker for AD and as an outcome measure for trials of disease-modifying therapies, particularly those targeted at the preservation and restoration of synapses.
PET kinetic analysis—compartmental model
TLDR
This review describes the principle of the compartmental model and categorizes the techniques and approaches for the compartmentAL model according to various aspects: model design, experimental design, invasiveness, and mathematical solution.
Adenosine A2A Receptors Measured with [11C]TMSX PET in the Striata of Parkinson's Disease Patients
TLDR
It is suggested that the A2ARs in the putamen compensate for the asymmetrical decrease of dopamine in drug-naïve PD patients and that antiparkinsonian therapy increases the A1A receptors in thePutamen.
Lower synaptic density is associated with depression severity and network alterations
TLDR
This is the first in vivo evidence linking lower synaptic density to network alterations and symptoms of depression, and provides further incentive to evaluate interventions that restore synaptic connections to treat depression.
Evaluation of distribution of adenosine A2A receptors in normal human brain measured with [11C]TMSX PET
TLDR
The distribution of the A2ARs in the living human brain is investigated using positron emission tomography (PET) and [7‐methyl‐11C]‐(E)‐8‐(3,4,5‐trimethoxystyryl)‐1,3,7‐ Trimethylxanthine ([ 11C]TMSX), the only promising PET ligand, which is available to clinical use for mapping the A 2ARs.
Association of in vivo κ-opioid receptor availability and the transdiagnostic dimensional expression of trauma-related psychopathology.
TLDR
Results of this study suggest that KOR availability in an amygdala-anterior cingulate cortex-ventral striatal neural circuit mediates the phenotypic expression of trauma-related loss (ie, dysphoria) symptoms and suggest that an activated corticotropin-releasing factor/hypothalamic-pituitary-adrenal axis system may indirectly mediate this association.
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