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A hierarchical cascade activated by non-canonical Notch signaling and the mTOR–Rictor complex regulates neglect-induced death in mammalian cells
The regulation of cellular metabolism and survival by trophic factors is not completely understood. Here, we describe a signaling cascade activated by the developmental regulator Notch, whichExpand
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Notch-activated signaling cascade interacts with mitochondrial remodeling proteins to regulate cell survival
Survival of differentiated cells is one of several processes regulated by Notch activity, although the general principles underlying this function remain to be characterized. Here, we probe theExpand
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The NEDD8 inhibitor MLN4924 increases the size of the nucleolus and activates p53 through the ribosomal-Mdm2 pathway
The ubiquitin-like molecule NEDD8 is essential for viability, growth and development, and is a potential target for therapeutic intervention. We found that the small molecule inhibitor ofExpand
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Protein kinase C δ is a critical regulator of CD1d-mediated antigen presentation
We have recently demonstrated that the p38 and ERK1/2 MAP kinases play reciprocal roles in the control of CD1d-mediated antigen presentation. Although the use of specific inhibitors for theseExpand
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Expression of Siglec-E Alters the Proteome of Lipopolysaccharide (LPS)-Activated Macrophages but Does Not Affect LPS-Driven Cytokine Production or Toll-Like Receptor 4 Endocytosis
Siglec-E is a murine CD33-related siglec that functions as an inhibitory receptor and is expressed mainly on neutrophils and macrophage populations. Recent studies have suggested that siglec-E is anExpand
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Identification of lectin counter-receptors on cell membranes by proximity labeling
Abstract Lectin–glycan interactions play important roles in many biological systems, but the nature of glycoprotein counter-receptors expressed on cell membranes is often poorly understood. To helpExpand
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Protein kinase C delta is a critical regulator of CD1d-mediated antigen presentation.
We have recently demonstrated that the p38 and ERK1/2 MAP kinases play reciprocal roles in the control of CD1d-mediated antigen presentation. Although the use of specific inhibitors for theseExpand
  • 3
The NEDD 8 inhibitor MLN 4924 increases the size of the nucleolus and activates p 53 through the ribosomal-Mdm 2 pathway
The ubiquitin-like molecule NEDD8 is essential for viability, growth and development, and is a potential target for therapeutic intervention. We found that the small molecule inhibitor ofExpand
  • 1
Towards understanding the cell surface phenotype, metabolic properties and immune functions of resident macrophages of the peritoneal cavity and splenic red pulp using high resolution
Resident macrophages (Mφs) are distributed throughout the Background: body and are important for maintaining tissue homeostasis and for defence against infections. Tissue Mφs are highly adapted toExpand
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