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Promoter-specific binding of Rap1 revealed by genome-wide maps of protein-DNA association
J.D. Lieb, X. Liu, D. Botstein & P.O. Brown Nature Genet. 28, 327–334 (2001). An error was introduced while preparing the paper for the press. It occurs in the first sentence of the fourth full
A Polymorphic Genomic Duplication on Human Chromosome 15 Is a Susceptibility Factor for Panic and Phobic Disorders
TLDR
An interstitial duplication of human chromosome 15q24-26 (named DUP25), which is significantly associated with panic/agoraphobia/social phobia/joint laxity in families, and with panic disorder in nonfamilial cases is identified.
Human chromosome 15q11-q14 regions of rearrangements contain clusters of LCR15 duplicons
TLDR
It is shown here that clusters containing several copies of the human chromosome 15 low-copy repeat (LCR15) duplicon are located at each of the six described 15q11-q14 BPs, and the results suggest the existence of breakpoints for large 15q 11-q13 deletions in a proximal duplicon-containing clone.
The human intersectin genes and their spliced variants are differentially expressed.
TLDR
The exon/intron structure of the ITSN2 gene is resolved to explain the genomic origin of its alternatively spliced transcripts, and a high level of conservation in their genomic organization is shown.
Mitotic recombination effects homozygosity for NF1 germline mutations in neurofibromas
TLDR
Pure populations of neurofibroma-derived Schwann cells bearing both NF1 mutated alleles (NF1−/−) have been isolated and mitotic recombination is the mechanism underlying this type of loss of heterozygosity leading to reduction to homozygosity of NF1 germline mutation.
Role of UEV-1, an Inactive Variant of the E2 UbiquitinConjugating Enzymes, in In Vitro Differentiation and Cell Cycle Behavior of HT-29-M6 Intestinal Mucosecretory Cells
TLDR
The results suggest that UEV proteins are involved in the control of differentiation and could exert their effects by altering cell cycle distribution.
Stromal interaction molecule 2 (STIM2) is frequently overexpressed in colorectal tumors and confers a tumor cell growth suppressor phenotype
TLDR
Several lines of evidence are presented indicating that STIM2 overexpression is a frequent trait in colorectal cancer that results in cell growth suppression, certifying that even in the absence of somatic genetic or epigenetic alterations, recurrent regions of LOH should still be considered a hallmark for the presence of relevant genes for tumorigenesis.
Molecular cloning, expression, and chromosomal localization of a ubiquitously expressed human 6-phosphofructo-2-kinase/ fructose-2,6-bisphosphatase gene (PFKFB3)
TLDR
Results identify the presence of a gene coding for a human 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase isozyme which is ubiquitously expressed.
Additional complexity on human chromosome 15q: identification of a set of newly recognized duplicons (LCR15) on 15q11-q13, 15q24, and 15q26.
TLDR
The construction of a BAC/PAC contig map is presented, which reveals the existence of several regions of sequence similarity with other chromosomes and with other 15q cytogenetic bands, and the identification of a set of new chromosome 15 duplicons.
PTOV1, a novel protein overexpressed in prostate cancer containing a new class of protein homology blocks
TLDR
In normal prostate tissue and in prostate adenomas, PTOV1 was undetectable or expressed at low levels, whereas nine out of 11 prostate adens showed a strong immunoreactivity, with a focal distribution in areas of carcinoma and prostatic intraepithelial neoplasia.
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