A Polymorphic Genomic Duplication on Human Chromosome 15 Is a Susceptibility Factor for Panic and Phobic Disorders
Human chromosome 15q11-q14 regions of rearrangements contain clusters of LCR15 duplicons
- M. Pujana, M. Nadal, M. Guitart, L. Armengol, M. Gratacós, X. Estivill
- BiologyEuropean Journal of Human Genetics
It is shown here that clusters containing several copies of the human chromosome 15 low-copy repeat (LCR15) duplicon are located at each of the six described 15q11-q14 BPs, and the results suggest the existence of breakpoints for large 15q 11-q13 deletions in a proximal duplicon-containing clone.
Promoter-specific binding of Rap1 revealed by genome-wide maps of protein-DNA association
The sentence “A preference for binding to intergenic regions, and more particularly to potential promoters, may be a general property of proteins that act at promoters but recognize DNA motifs that are found throughout the genome” should conclude: “.
The human intersectin genes and their spliced variants are differentially expressed.
Role of UEV-1, an Inactive Variant of the E2 UbiquitinConjugating Enzymes, in In Vitro Differentiation and Cell Cycle Behavior of HT-29-M6 Intestinal Mucosecretory Cells
The results suggest that UEV proteins are involved in the control of differentiation and could exert their effects by altering cell cycle distribution.
Mitotic recombination effects homozygosity for NF1 germline mutations in neurofibromas
Pure populations of neurofibroma-derived Schwann cells bearing both NF1 mutated alleles (NF1−/−) have been isolated and mitotic recombination is the mechanism underlying this type of loss of heterozygosity leading to reduction to homozygosity of NF1 germline mutation.
Additional complexity on human chromosome 15q: identification of a set of newly recognized duplicons (LCR15) on 15q11-q13, 15q24, and 15q26.
The construction of a BAC/PAC contig map is presented, which reveals the existence of several regions of sequence similarity with other chromosomes and with other 15q cytogenetic bands, and the identification of a set of new chromosome 15 duplicons.
Stromal interaction molecule 2 (STIM2) is frequently overexpressed in colorectal tumors and confers a tumor cell growth suppressor phenotype
Several lines of evidence are presented indicating that STIM2 overexpression is a frequent trait in colorectal cancer that results in cell growth suppression, certifying that even in the absence of somatic genetic or epigenetic alterations, recurrent regions of LOH should still be considered a hallmark for the presence of relevant genes for tumorigenesis.
Identification of somatic and germline mitochondrial DNA sequence variants in prostate cancer patients.
Molecular cloning, expression, and chromosomal localization of a ubiquitously expressed human 6-phosphofructo-2-kinase/ fructose-2,6-bisphosphatase gene (PFKFB3)
Results identify the presence of a gene coding for a human 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase isozyme which is ubiquitously expressed.