M. Nachman

Publications140
h-index65
Citations12,208
Highly Influential Citations809
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Estimate of the mutation rate per nucleotide in humans.
TLDR
Comparison of rates of evolution for X-linked and autosomal pseudogenes suggests that the male mutation rate is 4 times the female mutation rate, but provides no evidence for a reduction in mutation rate that is specific to the X chromosome. Expand
Genomics and the origin of species
TLDR
Emergent trends and gaps in understanding are identified, new approaches to more fully integrate genomics into speciation research are proposed, and an integrative definition of the field of speciation genomics is provided. Expand
Inferring the history of speciation in house mice from autosomal, X‐linked, Y‐linked and mitochondrial genes
TLDR
A survey of DNA‐sequence polymorphism and divergence at loci on the autosomes, X chromosome, Y chromosome and mitochondrial DNA in samples of Mus domesticus, M. musculus and M. castaneus suggests that these species started to diverge approximately 500 000 years ago. Expand
Subspecific origin and haplotype diversity in the laboratory mouse
TLDR
A genome-wide, high-resolution map of the phylogenetic origin of the genome of most extant laboratory mouse inbred strains is provided, based on the genotypes of wild-caught mice from three subspecies of Mus musculus. Expand
DIFFERENTIAL PATTERNS OF INTROGRESSION ACROSS THE X CHROMOSOME IN A HYBRID ZONE BETWEEN TWO SPECIES OF HOUSE MICE
TLDR
The utility of natural populations of hybrids for mapping speciation genes and suggests that the middle of the X chromosome may be important for reproductive isolation between species of house mice. Expand
Genome-wide patterns of gene flow across a house mouse hybrid zone.
TLDR
Patterns of linkage disequilibrium in the center of the hybrid zone suggest that isolation may be caused by multiple epistatic interactions between sets of genes, highlighting the complex genetic architecture underlying speciation even at early stages of divergence. Expand
Adaptation and constraint at Toll-like receptors in primates.
TLDR
Adaptive evolution at TLRs does not appear to reflect a constant turnover of alleles and instead might be more episodic in nature, which is consistent with more ephemeral pathogen-host associations rather than with long-term coevolution. Expand
Adaptive Introgression of Anticoagulant Rodent Poison Resistance by Hybridization between Old World Mice
TLDR
It is shown that resistant house mice can also originate from selection on vkorc1 polymorphisms acquired from the Algerian mouse (M. spretus) through introgressive hybridization, and positive selection produced an adaptive, divergent, and pleiotropic vKorc1 allele in the donor species, M. domesticus. Expand
Recombination rate variation and speciation: theoretical predictions and empirical results from rabbits and mice
  • M. Nachman, B. Payseur
  • Biology, Medicine
  • Philosophical Transactions of the Royal Society B…
  • 5 February 2012
TLDR
Both speciation and population-genetic models that make explicit predictions about how the rate of recombination influences patterns of genetic variation within and between species are reviewed and empirical data of DNA sequence variation in rabbits and mice is compared. Expand
The genetic basis of adaptive melanism in pocket mice
TLDR
The molecular changes underlying adaptive coat color variation in a natural population of rock pocket mice, Chaetodipus intermedius, are described and four mutations in the melanocortin-1-receptor gene seem to be responsible for adaptive melanism in one population of lava-dwelling pocket mice. Expand
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