• Publications
  • Influence
Generation and characterization of a rabbit monoclonal antibody site‐specific for tau O‐GlcNAcylated at serine 400
TLDR
The generation of a rabbit monoclonal antibody specific for tau O‐GlcNAcylated at Ser400 (O‐tau(S400)) is described and the utility of this antibody is shown for in vitro and in vivo experiments to investigate the function of O‐ GlcNAc modifications of tau atSer400. Expand
In vivo evidence that constitutive activity of serotonin2C receptors in the medial prefrontal cortex participates in the control of dopamine release in the rat nucleus accumbens: differential effects
TLDR
It is demonstrated that mPFC 5‐ HT2CRs facilitate activated accumbal DA outflow and that 5‐HT2CR constitutive activity participates in this interaction. Expand
PHASE 1 STUDY IN HEALTHY VOLUNTEERS OF THE O-GLCNACASE INHIBITOR ASN120290 AS A NOVEL THERAPY FOR PROGRESSIVE SUPRANUCLEAR PALSY AND RELATED TAUOPATHIES
O1-12-05 PHASE 1 STUDY IN HEALTHY VOLUNTEERS OF THE O-GLCNACASE INHIBITOR ASN120290 AS A NOVEL THERAPY FOR PROGRESSIVE SUPRANUCLEAR PALSYAND RELATED TAUOPATHIES J.Michael Ryan, AnnaQuattropani,Expand
Novel non-carbohydrate O-GlcNAcase inhibitors with CNS drug properties as potential treatment for Alzheimer’s disease and tauopathies
Novel non-carbohydrate O-GlcNAcase inhibitors with CNS drug properties as potential treatment for Alzheimer’s disease and tauopathies Heike Hering, Danielle Graham, Solenne Ousson, Maud Neny, AudreyExpand