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Population based study of late onset cerebellar ataxia in south east Wales
TLDR
A population based study of LOCA provides insight into LOCA within a defined region and will inform decisions about the rational use of healthcare resources for patients with LOCA.
Tualang Honey Protects the Rat Midbrain and Lung against Repeated Paraquat Exposure
TLDR
It is suggested that treatment with Tualang honey may protect against PQ-induced toxicity in the rat midbrain and lung and comparable to those of ubiquinol, which was used as a positive control.
Effect of tualang honey against KA-induced oxidative stress and neurodegeneration in the cortex of rats
TLDR
Pretreatment with Malaysian Tualang Honey has a therapeutic potential against KA-induced oxidative stress and neurodegeneration through its antioxidant effect, and attenuated an increase of thiobarbituric acid reactive substances level and a decrease of total antioxidant status level enhanced by KA in the cerebral cortex.
Tualang Honey Reduced Neuroinflammation and Caspase-3 Activity in Rat Brain after Kainic Acid-Induced Status Epilepticus
TLDR
Pretreatment with tualang honey reduced the elevation of TNF-α, IL-1β, GFAP, AIF-1, and COX-2 level in those brain regions at multiple time points and attenuated the increased caspase-3 activity in the cerebral cortex.
Chronic mitragynine (kratom) enhances punishment resistance in natural reward seeking and impairs place learning in mice
TLDR
It is found that chronic mitragynine treatment significantly potentiated horizontal exploratory activity and enhanced spontaneous sucrose preference and also its persistence when the preference had aversive consequences, but impairs learning and memory.
Anxiolytic-like effects of mitragynine in the open-field and elevated plus-maze tests in rats
TLDR
Findings reveal that the acute administration of mitragynine produces anxiolytic-like effects and this could be possibly attributed to the interactions among opioidergic, GABAergic and dopaminergic systems in brain regions involved in anxiety.
The genetic aetiology of late-onset chronic progressive cerebellar ataxia
TLDR
Patterns of highnormal allele frequency in this UK population were distinct compared to other ethnic groups but this was poorly predictive of the distribution of disease in this region.
An In–Laboratory Validity and Reliability Tested System for Quantifying Hand–Arm Tremor in Motions
TLDR
The moderate to very high clinical correlations of the system readings in measuring rest, postural and task-specific tremors add merits to the degree of readiness of the developed tremor measurement system in a routine clinical setting and/or intervention trial for tremor amelioration.
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