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Polymer translocation through a hole
The average residence time τ of a polymer of length N passing through a narrow hole under a chemical potential gradient is calculated. In the proposed model, details of the hole parametrize the rateExpand
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Polymer translocation through alpha-hemolysin pore with tunable polymer-pore electrostatic interaction.
We have measured the ionic current blockages produced by single molecules of sodium poly(styrene sulfonate) passing through an alpha-hemolysin protein pore under an electric field. Most of theExpand
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Electrostatic origin of the genome packing in viruses
Many ssRNA/ssDNA viruses bind their genome by highly basic semiflexible peptide arms of capsid proteins. Here, we show that nonspecific electrostatic interactions control both the length of theExpand
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Entropy and enthalpy of polyelectrolyte complexation: Langevin dynamics simulations.
We report a systematic study by Langevin dynamics simulation on the energetics of complexation between two oppositely charged polyelectrolytes of same charge density in dilute solutions of a goodExpand
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Polymer escape through a nanopore
Free energy barrier and mean translocation time, τ, are calculated for the movement of a single Gaussian chain from one sphere to another larger sphere through a narrow pore. The potentialExpand
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Langevin dynamics simulations of genome packing in bacteriophage.
We use Langevin dynamics simulations to study the process by which a coarse-grained DNA chain is packaged within an icosahedral container. We focus our inquiry on three areas of interest in viralExpand
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Theory of counter-ion condensation on flexible polyelectrolytes: adsorption mechanism.
  • M. Muthukumar
  • Chemistry, Medicine
  • The Journal of chemical physics
  • 29 April 2004
A new model is presented for counterion distribution around flexible polyelectrolytes by considering (i) free energy of the polyelectrolyte chain, (ii) translational entropy of adsorbed counterions,Expand
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Mechanism of DNA transport through pores.
  • M. Muthukumar
  • Chemistry, Medicine
  • Annual review of biophysics and biomolecular…
  • 3 May 2007
The transport of electrically charged macromolecules such as DNA through narrow pores is a fundamental process in life. When polymer molecules are forced to navigate through pores, their transport isExpand
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Theory of capture rate in polymer translocation.
  • M. Muthukumar
  • Materials Science, Medicine
  • The Journal of chemical physics
  • 21 May 2010
The translocation of macromolecules through a nanopore requires the impingement of the molecules at the pore followed by threading through the pore. While most of the discussion on the translocationExpand
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