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Successful pretreatment/therapy of soman, sarin and VX intoxication.
- W. J. Lennox, L. Harris, D. R. Anderson, R. P. Solana, M. Murrow, J. Wade
- Medicine, ChemistryDrug and chemical toxicology
Results indicate that, all of the PRG+T regimens, except BT-not tested with T, prevent lethality by soman; trihexyphenidyl and scopolamine (the only adjuncts used therein) regimens each prevent lethalities by sarin and VX.
Protection from lethality and behavioral incapacitation resulting from intoxication by soman (pinacolyl methylphosphonofluoridate) and treatment with atropine sulfate and 2-PAM chloride in the guinea…
Therapeutic treatment with ATR and 2-PAM produced a behavioral toxicity in its own right, an effect which lasted for at least three hours in the guinea pig, but this behavioral toxicity was lessened by reducing ATR dosage from 128 to 64 mg/kg, but 2- PAM dosage did not influence the behavioral toxicity of the treatment combinations within the range of dosages studied.
Effects of Methemoglobin Formers on Spontaneous Locomotor Activity and Methemoglobin Levels in Mice
Analysis of locomotor activity effects and MHb formation capacity of three MHb formers with established efficacy against CN support the idea that compounds producing low MHb levels can be effective against CN without debilitating side effects.
Effects of P-aminopropiophenone (PAPP), P-aminoheptanoylphenone (PAHP), and P-aminooctanoylphenone (PAOP) Exposure on Methemoglobin, Sulfhemoglobin, Oxyhemoglobin, Oxygen Content, Reduced Hemoglobin,…
Describing the hematologic effects of the MHb-forming compound p-aminopropiophenone (PAPP), and two structurally related phenones, p-aminoheptanoylphenone (PAHP) and PAOP, in mice provided information which will be useful for the successful development of improved anti-CN MHb formers.
Comparison of hematologic consequences and efficacy of p-aminophenones in mice.
SUCCESSFUL PRETREATMENT/THERAPY OF SOMAN, SARlN AND VX
Results indicate that, all of the PRG+T regimens, except BT-mt tested with T, prevent lethality by soman; trihexyphenidyl and scopolamine (the only adjuncts used therein) regimens each prevent lethalities by sarin and VX.
PROTECTION FROM LETHALITY AND BEHAVIORAL INCAPACITATION RESULTING FROM INTOXICATION BY SOMAN (PINACOLYL METHYLPHOSPHONO FLUORIDATE) AND TREATMENT
The lethal and incapacitating effects of the toxic organophosphorus (OP) agent, soman were evaluated in guinea pigs. The protective effects of the standard therapies atropine sulfate (ATR) and…