• Publications
  • Influence
Ketamine Enhances Human Neural Stem Cell Proliferation and Induces Neuronal Apoptosis via Reactive Oxygen Species–Mediated Mitochondrial Pathway
BACKGROUND:Growing evidence indicates that ketamine causes neurotoxicity in a variety of developing animal models, leading to a serious concern regarding the safety of pediatric anesthesia. However,Expand
  • 128
  • 7
Ketamine induces toxicity in human neurons differentiated from embryonic stem cells via mitochondrial apoptosis pathway.
Ketamine is widely used for anesthesia in pediatric patients. Growing evidence indicates that ketamine causes neurotoxicity in a variety of developing animal models. Our understanding of anesthesiaExpand
  • 63
  • 5
Endothelial-cardiomyocyte crosstalk enhances pharmacological cardioprotection.
Endothelial cells (EC) serve a paracrine function to enhance signaling in cardiomyocytes (CM), and conversely, CM secrete factors that impact EC function. Understanding how EC interact with CM may beExpand
  • 52
  • 5
Marked Hyperglycemia Attenuates Anesthetic Preconditioning in Human-induced Pluripotent Stem Cell-derived Cardiomyocytes
Introduction:Anesthetic preconditioning protects cardiomyocytes from oxidative stress-induced injury, but it is ineffective in patients with diabetes mellitus. To address the role of hyperglycemia inExpand
  • 30
  • 1
  • PDF
DNA damage and cell death assessment in patients with severe multiple trauma using comet assay
Purpose: To determine the DNA strand breaks, oxidative DNA damage and cell death in blood and plasma total antioxidant status (TAOS) in 22 patients with severe multiple trauma. Materials and methods:Expand
  • 2
  • 1
  • PDF
Targeted Modification of Mitochondrial ROS Production Converts High Glucose‐Induced Cytotoxicity to Cytoprotection: Effects on Anesthetic Preconditioning
Contradictory reports on the effects of diabetes and hyperglycemia on myocardial infarction range from cytotoxicity to cytoprotection. The study was designed to investigate acute effects of highExpand
  • 22
Cardioprotection during Diabetes: The Role of Mitochondrial DNA
Background:Diabetes alters mitochondrial bioenergetics and consequently disrupts cardioprotective signaling. The authors investigated whether mitochondrial DNA (mtDNA) modulates anestheticExpand
  • 14
  • PDF
Preconditioning by Isoflurane Elicits Mitochondrial Protective Mechanisms Independent of Sarcolemmal KATP Channel in Mouse Cardiomyocytes
Abstract: Cardiac mitochondria and the sarcolemmal (sarc)KATP channels contribute to cardioprotective signaling of anesthetic-induced preconditioning. Changes in mitochondrial bioenergetics influenceExpand
  • 4
Risk-stratification, resource availability, and choice of surgical location for the management of parturients with abnormal placentation: a survey of United States-based obstetric anesthesiologists.
BACKGROUND Parturients with abnormally adherent placentas present anesthetic challenges that include risk-stratification, management planning and resource utilization. The labor and delivery unit mayExpand
  • 2
  • PDF
Abstract P094: Anesthetic Preconditioning in Human Cardiomyocytes Derived from Type II Diabetic Patient-Induced Pluripotent Stem Cells in a Varying Glucose Environment
Volatile anesthetic-induced preconditioning (APC) has been shown to pharmacologically precondition the myocardium, providing protection from an ischemia-reperfusion injury. However, APC is attenuatedExpand