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AID is required to initiate Nbs1/γ-H2AX focus formation and mutations at sites of class switching
Class switch recombination (CSR) is a region-specific DNA recombination reaction that replaces one immunoglobulin heavy-chain constant region (Ch) gene with another. This enables a single variableExpand
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Constitutive Expression of AID Leads to Tumorigenesis
Genome stability is regulated by the balance between efficiencies of the repair machinery and genetic alterations such as mutations and chromosomal rearrangements. It has been postulated thatExpand
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Critical Roles of Activation-Induced Cytidine Deaminase in the Homeostasis of Gut Flora
Activation-induced cytidine deaminase (AID) plays an essential role in class switch recombination (CSR) and somatic hypermutation (SHM) of immunoglobulin genes. We report here that deficiency in AIDExpand
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PD-1 and LAG-3 inhibitory co-receptors act synergistically to prevent autoimmunity in mice
A new mouse model of spontaneous autoimmune disease reveals an important role for the inhibitory co-receptor LAG-3 in suppressing autoimmunity.
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Discovery of activation-induced cytidine deaminase, the engraver of antibody memory.
Discovery of activation-induced cytidine deaminase (AID) paved a new path to unite two genetic alterations induced by antigen stimulation; class switch recombination (CSR) and somatic hypermutationExpand
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DNA double-strand breaks: prior to but not sufficient in targeting hypermutation.
The activation-induced cytidine deaminase (AID) is required for somatic hypermutation (SHM) and class-switch recombination (CSR) of immunoglobulin (Ig) genes, both of which are associated with DNAExpand
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Epstein-Barr Virus Latent Membrane Protein 1 Induces Cancer Stem/Progenitor-Like Cells in Nasopharyngeal Epithelial Cell Lines
ABSTRACT Recent studies suggest the existence of cancer stem cells (CSC) and cancer progenitor cells (CPC), although strict definitions of neither CSC nor CPC have been developed. We have producedExpand
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CXCR5-Dependent Seeding of Follicular Niches by B and Th Cells Augments Antiviral B Cell Responses1
The chemokine receptor CXCR5 and its ligand CXCL13 define the structure of B cell follicles within secondary lymphoid organs. Here, we examined the impact of CXCR5 on antiviral B cell responses inExpand
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Type two hyper-IgM syndrome caused by mutation in activation-induced cytidine deaminase.
Thirteen Japanese patients with hyper-IgM syndrome but normal CD40 ligand were characterized. All patients had mutations in AID (activation-induced cytidine deaminase) gene. Five of them had aExpand
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IgG and IgE Collaboratively Accelerate Expulsion of Strongyloides venezuelensis in a Primary Infection
ABSTRACT The host deploys a subset of immune responses to expel helminths, which differs depending on the nature of the helminth. Strongyloides venezuelensis, a counterpart of the human pathogen S.Expand
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