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Chronic neuropathological and neurobehavioral changes in a repetitive mild traumatic brain injury model
Traumatic brain injury (TBI) is a recognized risk factor for later development of neurodegenerative disease. However, the mechanisms contributing to neurodegeneration following TBI remain obscure.
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Progressive and gender-dependent cognitive impairment in the APPSW transgenic mouse model for Alzheimer’s disease
To determine if early cognitive sensorimotor deficits exist in APP(SW) transgenic mice overexpressing human amyloid precursor protein (APP). Tg+ and Tg- animals at both 3 and 9 months of age (3M andExpand
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Adaptation of the circular platform spatial memory task for mice: use in detecting cognitive impairment in the APPSW transgenic mouse model for Alzheimer’s disease
A methodology is described for use of a 16-hole circular platform task to test spatial memory in mice. Both bright light and a fan were used to motivate mice to escape the platform surface through aExpand
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Inflammatory cytokine levels correlate with amyloid load in transgenic mouse models of Alzheimer's disease
BackgroundInflammation is believed to play an important role in the pathology of Alzheimer's disease (AD) and cytokine production is a key pathologic event in the progression of inflammatoryExpand
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Plasma microRNA biomarkers for detection of mild cognitive impairment
Early stages of many neurodegenerative diseases, such as Alzheimer's disease, vascular and frontotemporal dementia, and Parkinson's disease, are frequently associated with Mild Cognitive ImpairmentExpand
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A Multifaceted Role for apoE in the Clearance of Beta-Amyloid across the Blood-Brain Barrier
Background: While apolipoprotein E4 (apoE4) is highly correlated with the development of Alzheimer’s disease (AD), its role in AD pathology and, in particular, beta-amyloid (Aβ) removal from theExpand
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Anti-inflammatory activity of anatabine via inhibition of STAT3 phosphorylation.
Previous investigations have demonstrated the anti-inflammatory effects of cholinergic agonists, such as nicotine. In the present study, we investigated the potential anti-inflammatory activity ofExpand
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APOE genotype influences acquisition and recall following traumatic brain injury
Abstract—APOE has been demonstrated to influence traumatic brain injury (TBI) outcome. The relationship between APOE genotype and memory following TBI was examined in 110 participants in the DefenseExpand
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Selective Antihypertensive Dihydropyridines Lower Aβ Accumulation by Targeting both the Production and the Clearance of Aβ across the Blood-Brain Barrier
Several large population-based or clinical trial studies have suggested that certain dihydropyridine (DHP) L-type calcium channel blockers (CCBs) used for the treatment of hypertension may conferExpand
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Cocaine-induced oxidative stress precedes cell death in human neuronal progenitor cells
By 2003, an estimated 34 million Americans had used cocaine according to the National Survey on Drug Use & Health. About 5.9 million of those had used in the past 12 months. Chronic cocaine usersExpand
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