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Both the Suppressor of Cytokine Signaling 1 (SOCS-1) Kinase Inhibitory Region and SOCS-1 Mimetic Bind to JAK2 Autophosphorylation Site: Implications for the Development of a SOCS-1 Antagonist1
Suppressor of cytokine signaling (SOCS)-1 protein modulates signaling by IFN-γ by binding to the autophosphorylation site of JAK2 and by targeting bound JAK2 to the proteosome for degradation. WeExpand
Characterization of a Peptide Inhibitor of Janus Kinase 2 That Mimics Suppressor of Cytokine Signaling 1 Function1
TLDR
A short 12-mer peptide is developed, WLVFFVIFYFFR, that binds to the autophosphorylation site of JAK2, resulting in inhibition of its autoph phosphorylated site as well as its phosphorylation of IFN-γ receptor subunit IFNGR-1, a proof-of-concept demonstration of a peptide mimetic of SOCS-1 that regulates Jak2 tyrosine kinase function. Expand
Treatment of Mice with the Suppressor of Cytokine Signaling-1 Mimetic Peptide, Tyrosine Kinase Inhibitor Peptide, Prevents Development of the Acute Form of Experimental Allergic Encephalomyelitis and
TLDR
The data presented in this study show that Tkip, like the type I IFN, IFN-τ, inhibits both the autoreactive cellular and humoral responses in EAE and ameliorates both the acute and chronic relapsing/remitting forms of EAE. Expand
Amitriptyline versus Bupivacaine in Rat Sciatic Nerve Blockade
TLDR
Findings suggest that amitriptyline could extend its clinical usefulness for peripheral nerve blockade and is a more potent blocker of neuronal Na+ channels than bupivacaine in vivo and in vitro. Expand
N-Phenylethyl Amitriptyline in Rat Sciatic Nerve Blockade
TLDR
N-phenylethyl amitriptyline appears to have a narrow therapeutic range but is much more potent than lidocaine, providing a block duration several times longer than any clinically used local anesthetic. Expand
Oral feeding of interferon τ can prevent the acute and chronic relapsing forms of experimental allergic encephalomyelitis
TLDR
Oral feeding of ovine IFn tau may be a successful form of IFN tau administration for treatment of autoimmune diseases such as MS and may circumvent potentially debilitative antibody responses. Expand
Assessment of Differential Blockade by Amitriptyline and Its N-Methyl Derivative in Different Species by Different Routes
TLDR
Amitriptyline and N-methyl amitriptylines are potent Na+ channel blockers and show greater differential blockade in sheep than in rats, which is greater than that produced by lidocaine or bupivacaine. Expand
The COOH-terminal nuclear localization sequence of interferon gamma regulates STAT1 alpha nuclear translocation at an intracellular site.
TLDR
The C-terminal NLS region appears to contribute minimally to extracellular high-affinity receptor-ligand binding, yet exerts a strong functional role in STAT1 alpha nuclear localization. Expand
The role of IFNγ nuclear localization sequence in intracellular function
TLDR
It is shown that extracellularly added IFNγ possesses intracellular signaling activity that is NLS dependent, as suggested by previous studies, and that this activity occurs via the receptor-mediated endocytosis of IFNα. Expand
Superantigen Enhancement of Specific Immunity: Antibody Production and Signaling Pathways1
TLDR
Superantigens enhance humoral immunity via Ag-specific CD4+ T cells involving the stress-independent pathway of MAP kinase, which is an important component of the eukaryotic protein synthesis initiation complex. Expand
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